SELPLG and SELP single-nucleotide polymorphisms in multiple sclerosis

Chiara Fenoglio; Daniela Galimberti; Maria Ban; Mel Maranian; Diego Scalabrini; Eliana Venturelli; Laura Piccio; Milena De Riz; Tai Wai Yeo; An Goris; Julia Gray; Nereo Bresolin; Elio Scarpini; Alastair Compston; Stephen Sawcer

doi:10.1016/j.neulet.2005.10.014

SELPLG and SELP single-nucleotide polymorphisms in multiple sclerosis

Chiara Fenoglio, Daniela Galimberti, Maria Ban, Mel Maranian, Diego Scalabrini, Eliana Venturelli, Laura Piccio, Milena De Riz, Tai Wai Yeo, An Goris, Julia Gray, Nereo Bresolin, Elio Scarpini, Alastair Compston, Stephen Sawcer

Research output: Contribution to journal › Article › peer-review

14 Scopus citations

Abstract

P-Selectin (SELP) and P-selectin glycoprotein ligand-1 (SELPLG) constitute a receptor/ligand complex involved in the recruitment of activated lymphocytes, a critical event in the pathogenesis of multiple sclerosis (MS). In order to determine whether genetic variation in these pivotal molecules influences susceptibility to MS, we genotyped 214 Italian patients compared with 220 Italian controls for three single-nucleotide polymorphisms (SNPs): SELPLG Met62Ile, SELP C-2123G and SELP Thr715Pro. No significant differences in both SELP SNPs were found between patients and controls, whereas a decreased frequency of the Met62Ile SNP was found in patients versus controls in the Italian population (P = 0.025). To confirm these preliminary findings, the Met62Ile SNP was analysed in 938 UK trio families. This SNP did not show evidence for association with susceptibility to MS in the larger UK cohort. Therefore, none of the SNPs investigated is associated with MS, although this analysis does not conclusively exclude SELPLG and SELP as genetic risk factors for MS as much variation remains untested.

Original language	English
Pages (from-to)	92-96
Number of pages	5
Journal	Neuroscience Letters
Volume	394
Issue number	2
DOIs	https://doi.org/10.1016/j.neulet.2005.10.014
State	Published - Feb 13 2006

Keywords

Adhesion molecules
Multiple sclerosis
Polymorphism
SELP
SELPLG

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10.1016/j.neulet.2005.10.014

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@article{b358712b395747a4b382519cbffdfcb0,

title = "SELPLG and SELP single-nucleotide polymorphisms in multiple sclerosis",

abstract = "P-Selectin (SELP) and P-selectin glycoprotein ligand-1 (SELPLG) constitute a receptor/ligand complex involved in the recruitment of activated lymphocytes, a critical event in the pathogenesis of multiple sclerosis (MS). In order to determine whether genetic variation in these pivotal molecules influences susceptibility to MS, we genotyped 214 Italian patients compared with 220 Italian controls for three single-nucleotide polymorphisms (SNPs): SELPLG Met62Ile, SELP C-2123G and SELP Thr715Pro. No significant differences in both SELP SNPs were found between patients and controls, whereas a decreased frequency of the Met62Ile SNP was found in patients versus controls in the Italian population (P = 0.025). To confirm these preliminary findings, the Met62Ile SNP was analysed in 938 UK trio families. This SNP did not show evidence for association with susceptibility to MS in the larger UK cohort. Therefore, none of the SNPs investigated is associated with MS, although this analysis does not conclusively exclude SELPLG and SELP as genetic risk factors for MS as much variation remains untested.",

keywords = "Adhesion molecules, Multiple sclerosis, Polymorphism, SELP, SELPLG",

author = "Chiara Fenoglio and Daniela Galimberti and Maria Ban and Mel Maranian and Diego Scalabrini and Eliana Venturelli and Laura Piccio and {De Riz}, Milena and Yeo, {Tai Wai} and An Goris and Julia Gray and Nereo Bresolin and Elio Scarpini and Alastair Compston and Stephen Sawcer",

note = "Funding Information: This work was supported by grants from Associazione Amici del “Centro Dino Ferrari”, IRCCS Ospedale Maggiore Milano, Center of Excellence for Neurodegenerative Diseases of the University of Milan, the Multiple Sclerosis Society of Great Britain and Northern Ireland and the Wellcome Trust. Dr. Fenoglio was recipient of a fellowship by the European Neurological Society (ENS). We would also like to thank the patients and their families for taking part in these studies.",

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doi = "10.1016/j.neulet.2005.10.014",

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journal = "Neuroscience Letters",

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TY - JOUR

T1 - SELPLG and SELP single-nucleotide polymorphisms in multiple sclerosis

AU - Fenoglio, Chiara

AU - Galimberti, Daniela

AU - Ban, Maria

AU - Maranian, Mel

AU - Scalabrini, Diego

AU - Venturelli, Eliana

AU - Piccio, Laura

AU - De Riz, Milena

AU - Yeo, Tai Wai

AU - Goris, An

AU - Gray, Julia

AU - Bresolin, Nereo

AU - Scarpini, Elio

AU - Compston, Alastair

AU - Sawcer, Stephen

N1 - Funding Information: This work was supported by grants from Associazione Amici del “Centro Dino Ferrari”, IRCCS Ospedale Maggiore Milano, Center of Excellence for Neurodegenerative Diseases of the University of Milan, the Multiple Sclerosis Society of Great Britain and Northern Ireland and the Wellcome Trust. Dr. Fenoglio was recipient of a fellowship by the European Neurological Society (ENS). We would also like to thank the patients and their families for taking part in these studies.

PY - 2006/2/13

Y1 - 2006/2/13

N2 - P-Selectin (SELP) and P-selectin glycoprotein ligand-1 (SELPLG) constitute a receptor/ligand complex involved in the recruitment of activated lymphocytes, a critical event in the pathogenesis of multiple sclerosis (MS). In order to determine whether genetic variation in these pivotal molecules influences susceptibility to MS, we genotyped 214 Italian patients compared with 220 Italian controls for three single-nucleotide polymorphisms (SNPs): SELPLG Met62Ile, SELP C-2123G and SELP Thr715Pro. No significant differences in both SELP SNPs were found between patients and controls, whereas a decreased frequency of the Met62Ile SNP was found in patients versus controls in the Italian population (P = 0.025). To confirm these preliminary findings, the Met62Ile SNP was analysed in 938 UK trio families. This SNP did not show evidence for association with susceptibility to MS in the larger UK cohort. Therefore, none of the SNPs investigated is associated with MS, although this analysis does not conclusively exclude SELPLG and SELP as genetic risk factors for MS as much variation remains untested.

AB - P-Selectin (SELP) and P-selectin glycoprotein ligand-1 (SELPLG) constitute a receptor/ligand complex involved in the recruitment of activated lymphocytes, a critical event in the pathogenesis of multiple sclerosis (MS). In order to determine whether genetic variation in these pivotal molecules influences susceptibility to MS, we genotyped 214 Italian patients compared with 220 Italian controls for three single-nucleotide polymorphisms (SNPs): SELPLG Met62Ile, SELP C-2123G and SELP Thr715Pro. No significant differences in both SELP SNPs were found between patients and controls, whereas a decreased frequency of the Met62Ile SNP was found in patients versus controls in the Italian population (P = 0.025). To confirm these preliminary findings, the Met62Ile SNP was analysed in 938 UK trio families. This SNP did not show evidence for association with susceptibility to MS in the larger UK cohort. Therefore, none of the SNPs investigated is associated with MS, although this analysis does not conclusively exclude SELPLG and SELP as genetic risk factors for MS as much variation remains untested.

KW - Adhesion molecules

KW - Multiple sclerosis

KW - Polymorphism

KW - SELP

KW - SELPLG

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SN - 0304-3940

VL - 394

SP - 92

EP - 96

JO - Neuroscience Letters

JF - Neuroscience Letters

IS - 2

ER -

SELPLG and SELP single-nucleotide polymorphisms in multiple sclerosis

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Keywords

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