SELPLG and SELP single-nucleotide polymorphisms in multiple sclerosis

Chiara Fenoglio, Daniela Galimberti, Maria Ban, Mel Maranian, Diego Scalabrini, Eliana Venturelli, Laura Piccio, Milena De Riz, Tai Wai Yeo, An Goris, Julia Gray, Nereo Bresolin, Elio Scarpini, Alastair Compston, Stephen Sawcer

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11 Scopus citations

Abstract

P-Selectin (SELP) and P-selectin glycoprotein ligand-1 (SELPLG) constitute a receptor/ligand complex involved in the recruitment of activated lymphocytes, a critical event in the pathogenesis of multiple sclerosis (MS). In order to determine whether genetic variation in these pivotal molecules influences susceptibility to MS, we genotyped 214 Italian patients compared with 220 Italian controls for three single-nucleotide polymorphisms (SNPs): SELPLG Met62Ile, SELP C-2123G and SELP Thr715Pro. No significant differences in both SELP SNPs were found between patients and controls, whereas a decreased frequency of the Met62Ile SNP was found in patients versus controls in the Italian population (P = 0.025). To confirm these preliminary findings, the Met62Ile SNP was analysed in 938 UK trio families. This SNP did not show evidence for association with susceptibility to MS in the larger UK cohort. Therefore, none of the SNPs investigated is associated with MS, although this analysis does not conclusively exclude SELPLG and SELP as genetic risk factors for MS as much variation remains untested.

Original languageEnglish
Pages (from-to)92-96
Number of pages5
JournalNeuroscience Letters
Volume394
Issue number2
DOIs
StatePublished - Feb 13 2006
Externally publishedYes

Keywords

  • Adhesion molecules
  • Multiple sclerosis
  • Polymorphism
  • SELP
  • SELPLG

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    Fenoglio, C., Galimberti, D., Ban, M., Maranian, M., Scalabrini, D., Venturelli, E., Piccio, L., De Riz, M., Yeo, T. W., Goris, A., Gray, J., Bresolin, N., Scarpini, E., Compston, A., & Sawcer, S. (2006). SELPLG and SELP single-nucleotide polymorphisms in multiple sclerosis. Neuroscience Letters, 394(2), 92-96. https://doi.org/10.1016/j.neulet.2005.10.014