Self-assembling nanoclusters in living systems: application for integrated photothermal nanodiagnostics and nanotherapy

Vladimir P. Zharov, Jin Woo Kim, David T. Curiel, Maaike Everts

Research output: Contribution to journalArticle

177 Scopus citations

Abstract

Nanotechnologies represent an unprecedented recent advance that may revolutionize many areas of medicine and biology, including cancer diagnostics and treatment. Nanoparticle-based technologies have demonstrated especially high potential for medical purposes, ranging from diagnosing diseases to providing novel therapies. However, to be clinically relevant, the existing nanoparticle-based technologies must overcome several challenges, including selective nanoparticle delivery, potential cytotoxicity, imaging of nanoparticles, and real-time assessment of their therapeutic efficacy. This review addresses these issues by summarizing the recent advances in medical diagnostics and therapy with a focus on the self-assembly of gold nanoparticles into nanoclusters in live cells, in combination with their detection using photothermal (PT) techniques.

Original languageEnglish
Pages (from-to)326-345
Number of pages20
JournalNanomedicine: Nanotechnology, Biology, and Medicine
Volume1
Issue number4
DOIs
StatePublished - Dec 1 2005
Externally publishedYes

Keywords

  • Adenovirus
  • Bio/abio interfacing
  • Cancer cell
  • Gene therapy
  • Nanoclusters
  • Nanoparticles
  • Photothermal imaging
  • Selective photothermolysis
  • Self-assembly

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