TY - JOUR
T1 - Self-assembling nanoclusters in living systems
T2 - application for integrated photothermal nanodiagnostics and nanotherapy
AU - Zharov, Vladimir P.
AU - Kim, Jin Woo
AU - Curiel, David T.
AU - Everts, Maaike
PY - 2005/12/1
Y1 - 2005/12/1
N2 - Nanotechnologies represent an unprecedented recent advance that may revolutionize many areas of medicine and biology, including cancer diagnostics and treatment. Nanoparticle-based technologies have demonstrated especially high potential for medical purposes, ranging from diagnosing diseases to providing novel therapies. However, to be clinically relevant, the existing nanoparticle-based technologies must overcome several challenges, including selective nanoparticle delivery, potential cytotoxicity, imaging of nanoparticles, and real-time assessment of their therapeutic efficacy. This review addresses these issues by summarizing the recent advances in medical diagnostics and therapy with a focus on the self-assembly of gold nanoparticles into nanoclusters in live cells, in combination with their detection using photothermal (PT) techniques.
AB - Nanotechnologies represent an unprecedented recent advance that may revolutionize many areas of medicine and biology, including cancer diagnostics and treatment. Nanoparticle-based technologies have demonstrated especially high potential for medical purposes, ranging from diagnosing diseases to providing novel therapies. However, to be clinically relevant, the existing nanoparticle-based technologies must overcome several challenges, including selective nanoparticle delivery, potential cytotoxicity, imaging of nanoparticles, and real-time assessment of their therapeutic efficacy. This review addresses these issues by summarizing the recent advances in medical diagnostics and therapy with a focus on the self-assembly of gold nanoparticles into nanoclusters in live cells, in combination with their detection using photothermal (PT) techniques.
KW - Adenovirus
KW - Bio/abio interfacing
KW - Cancer cell
KW - Gene therapy
KW - Nanoclusters
KW - Nanoparticles
KW - Photothermal imaging
KW - Selective photothermolysis
KW - Self-assembly
UR - http://www.scopus.com/inward/record.url?scp=33645212922&partnerID=8YFLogxK
U2 - 10.1016/j.nano.2005.10.006
DO - 10.1016/j.nano.2005.10.006
M3 - Article
C2 - 17292107
AN - SCOPUS:33645212922
VL - 1
SP - 326
EP - 345
JO - Nanomedicine: Nanotechnology, Biology, and Medicine
JF - Nanomedicine: Nanotechnology, Biology, and Medicine
SN - 1549-9634
IS - 4
ER -