Self-assembled hybrid nanoparticles for cancer-specific multimodal imaging

Jason S. Kim, William J. Rieter, Kathryn M.L. Taylor, Hongyu An, Weili Lin, Wenbin Lin

Research output: Contribution to journalArticle

181 Scopus citations

Abstract

A layer-by-layer (LbL) polyelectrolyte deposition strategy is used to prepare multifunctional nanoparticles (MFNPs) with multimodal imaging capabilities. Alternating treatment of hybrid silica nanoparticles (NP0) containing a luminescent [Ru(bpy)3]Cl2 core and anionic monolayer coating of the Gd-(siloxylpropyl)diethylenetriamine tetraacetate (Gd-DTTA) complex with cationic Gd(III)-DOTA oligomer 1 and anionic poly(styrene sulfonate) (PSS) led to the deposition of multilayers of 1 and PSS via electrostatic interactions. This LbL deposition technique offers a superb strategy for the assembly of hybrid nanoparticles with imbedded luminophores and very high MR relaxivities. The PSS-terminated multilayered nanoparticles can be noncovalently functionalized with targeting peptides that carry positive charges under physiological conditions via electrostatic interactions to lead to cancer-specific MFNPs for optical and MR imaging of HT-29 human colon cancer cells. The generality of this approach should allow the design of imaging and/or therapeutic MFNPs that can specifically target a wide range of diseased cells.

Original languageEnglish
Pages (from-to)8962-8963
Number of pages2
JournalJournal of the American Chemical Society
Volume129
Issue number29
DOIs
StatePublished - Jul 25 2007
Externally publishedYes

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