TY - JOUR
T1 - Selective localization of radioiodinated alkylphosphocholine derivatives in tumors
AU - Plotzke, Kathleen P.
AU - Haradahira, Terushi
AU - Stancato, Louis
AU - Olken, Norman M.
AU - Skinner, Scott
AU - Gross, Milton D.
AU - Wahl, Richard L.
AU - Counsell, Raymond E.
N1 - Funding Information:
Acknowledgemenfs-Tahuet horsw ish to thank Dr James Varani of the Departmento f Pathologyf or providing the Walker 256c arcinosarcomcae llsa nd MS Eddie Quenbyf or her technicala ssistancew ith the tissued istributions tudies. The authors also wish to expresst heir appreciationt o MS Alice Sannesa nd Mr Mark Rampy for their technical assistancew ith the preparationo f the manuscriptS. upport for this researchw as provided by the National Institute of Health grant (CA-08349)a nd the RackhamS chool of GraduateS tudiesR esearchP artnershipF ellowship.
PY - 1992/10
Y1 - 1992/10
N2 - We have designed and synthesized two radioiodinated analogs of hexadecylphosphocholine in order to evaluate their tumor imaging potential. 12-(m[125I]iodophenyl)dodecyl phosphocholine (NM-324) and hexadecyl-2-[N,N-dimethyl-N-(m[125I]iodobenzyl-ammonium]ethyl phosphate (NM-326) demonstrated the ability of such compounds to localize in and thereby visualize the Walker 256 tumor in rats. However, the tumor avidity of NM-324 was far superior to NM-326. In addition, NM-324 showed excellent tumor localization in athymic mice bearing subcutaneous human tumors.
AB - We have designed and synthesized two radioiodinated analogs of hexadecylphosphocholine in order to evaluate their tumor imaging potential. 12-(m[125I]iodophenyl)dodecyl phosphocholine (NM-324) and hexadecyl-2-[N,N-dimethyl-N-(m[125I]iodobenzyl-ammonium]ethyl phosphate (NM-326) demonstrated the ability of such compounds to localize in and thereby visualize the Walker 256 tumor in rats. However, the tumor avidity of NM-324 was far superior to NM-326. In addition, NM-324 showed excellent tumor localization in athymic mice bearing subcutaneous human tumors.
UR - https://www.scopus.com/pages/publications/44049113278
U2 - 10.1016/0883-2897(92)90138-O
DO - 10.1016/0883-2897(92)90138-O
M3 - Article
C2 - 1399698
AN - SCOPUS:44049113278
SN - 0883-2897
VL - 19
SP - 765
EP - 773
JO - International Journal of Radiation Applications and Instrumentation.
JF - International Journal of Radiation Applications and Instrumentation.
IS - 7
ER -