Selective localization of radioiodinated alkylphosphocholine derivatives in tumors

Kathleen P. Plotzke, Terushi Haradahira, Louis Stancato, Norman M. Olken, Scott Skinner, Milton D. Gross, Richard L. Wahl, Raymond E. Counsell

Research output: Contribution to journalArticle

7 Scopus citations

Abstract

We have designed and synthesized two radioiodinated analogs of hexadecylphosphocholine in order to evaluate their tumor imaging potential. 12-(m[125I]iodophenyl)dodecyl phosphocholine (NM-324) and hexadecyl-2-[N,N-dimethyl-N-(m[125I]iodobenzyl-ammonium]ethyl phosphate (NM-326) demonstrated the ability of such compounds to localize in and thereby visualize the Walker 256 tumor in rats. However, the tumor avidity of NM-324 was far superior to NM-326. In addition, NM-324 showed excellent tumor localization in athymic mice bearing subcutaneous human tumors.

Original languageEnglish
Pages (from-to)765-773
Number of pages9
JournalInternational Journal of Radiation Applications and Instrumentation.
Volume19
Issue number7
DOIs
StatePublished - Oct 1992
Externally publishedYes

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