Selective IgM deficiency in CD30+ cutaneous lymphoproliferative disorder

Surbhi Saini, Andrew J. Dettore, Kanta J. Bhambhani, Steven Buck, Janet Poulik, Süreyya Savaşan

Research output: Contribution to journalArticle

6 Scopus citations

Abstract

Primary cutaneous anaplastic large cell lymphoma with local lymph node involvement was diagnosed in a 13-year-old boy with an ulcerative facial lesion and a history of skin lesions of lymphomatoid papulosis. The tumor regressed with chemotherapy. He continued to develop recurrent self-limited lesions of lymphomatoid papulosis , with a halo surrounding these lesions during the healing phase. He developed selective immunoglobulin M deficiency with decline in levels even 4 years after the chemotherapy with no recurrent infections noted and adequate IgG response to immunizations. Both peripheral blood IgM and memory B cells were low, suggesting a possible cause-effect relationship between selective immunoglobulin M deficiency and chronic CD30 cutaneous lymphoproliferative disorders.

Original languageEnglish
Pages (from-to)e156-e159
JournalJournal of Pediatric Hematology/Oncology
Volume33
Issue number4
DOIs
StatePublished - May 1 2011
Externally publishedYes

Keywords

  • halo lesions
  • lymphomatoid papulosis
  • memory B cells
  • primary cutaneous anaplastic large cell lymphoma
  • selective IgM deficiency

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