Abstract
NOTCH1, which is frequently mutated in T cell acute lymphoblastic leukemia, has been an elusive therapeutic target. In this issue of Cancer Cell, Roti and colleagues demonstrate that inhibiting SERCA calcium pumps preferentially impairs the maturation of the most common class of oncogenic Notch1 mutants, thus uncovering a potential therapeutic avenue.
Original language | English |
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Pages (from-to) | 267-269 |
Number of pages | 3 |
Journal | Cancer Cell |
Volume | 23 |
Issue number | 3 |
DOIs | |
State | Published - Mar 18 2013 |