Selective blockade of transport via SERCA inhibition: The Answer for oncogenic forms of notch?

Ma Xenia G. Ilagan, Raphael Kopan

Research output: Contribution to journalShort survey

16 Scopus citations

Abstract

NOTCH1, which is frequently mutated in T cell acute lymphoblastic leukemia, has been an elusive therapeutic target. In this issue of Cancer Cell, Roti and colleagues demonstrate that inhibiting SERCA calcium pumps preferentially impairs the maturation of the most common class of oncogenic Notch1 mutants, thus uncovering a potential therapeutic avenue.

Original languageEnglish
Pages (from-to)267-269
Number of pages3
JournalCancer Cell
Volume23
Issue number3
DOIs
StatePublished - Mar 18 2013

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