Selective ablation of virion host shutoff protein RNase activity attenuates herpes simplex virus 2 in mice

Keyphrases

• Central Nervous System 9%
• Complex Role 9%
• Disease Severity 18%
• Disease Spread 9%
• Endoribonuclease Activity 9%
• Enzymatic Activity 9%
• Herpes Simplex Virus 9%
• Herpes Simplex Virus 2 (HSV-2) 100%
• Herpes Simplex Virus Type 1 (HSV-1) 9%
• Infected Cells 9%
• Interferon Receptor Knockout 9%
• Interferon Resistance 18%
• Interferon-α (IFN-α) 9%
• Interferon-β (IFN-β) 9%
• Knock-in Mouse Model 9%
• Nervous System 9%
• Point mutant 9%
• Point mutation 9%
• Protein Synthesis 9%
• Ribonuclease 36%
• RNA Degradation 9%
• RNase Activity 100%
• Selective Ablation 100%
• Truncation mutants 18%
• Type I Interferon 18%
• Type I Interferon Response 18%
• Vaginal Swab 9%
• Virion 9%
• Virion Host Shutoff 100%
• Virion Host Shutoff Protein 100%
• Virulence 18%
• Virus 36%
• Virus Replication 9%
• Virus Titer 9%
• VP16 9%
• VP22 9%
• Wild Mice 9%
• Wild Type Virus 9%

Immunology and Microbiology

• Central Nervous System 5%
• Enzyme Activity 5%
• Herpes Simplex Virus 5%
• Herpes Simplex Virus 2 100%
• Human Alphaherpesvirus 1 5%
• interferon 25%
• Interferon-Alpha/Beta Receptor 5%
• Knockout Mouse 5%
• Mouse 100%
• Nervous System 5%
• Point Mutation 5%
• Protein Synthesis 5%
• Viral Load 5%
• Viral Replication 5%
• Virion 100%
• Virus Type 5%
• Wild Type 15%
• Wild Type Mouse 5%