Selection of optimal axon ratio for nerve regeneration

S. E. Mackinnon, A. L. Dellon, J. P. O'Brien, N. Goldberg, D. A. Hunter, W. A. Seiler, J. Carlton

Research output: Contribution to journalArticlepeer-review

35 Scopus citations


The traditional teaching that 'nerve fibers are lost at the suture line' after a nerve repair was investigated by asking the question. 'Can the number of nerve fibers distal to a nerve repair site be increased by increasing the number of nerve fibers proximally?' Ratios of proximal to distal nerve fibers were increased from 1:1 to 2.5:1 to 3.5:1 by suturing peroneal or posterior tibial or sciatic nerve proximally to peroneal nerve fiber numbers increased to twice normal as the ratio increased to 2.5:1, and then nerve fiber numbers plateaued. Nerve function, as judged by walking track analysis, was best in the peroneal:peroneal group (1:1 ratio), suggesting that appropriateness rather than number of proximal fibers was more critical in this nerve repair model.

Original languageEnglish
Pages (from-to)129-134
Number of pages6
JournalAnnals of Plastic Surgery
Issue number2
StatePublished - 1989


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