Selection at a single locus leads to widespread expansion of toxoplasma gondii lineages that are virulent in mice

Keyphrases

• Adaptation 16%
• Avirulent 16%
• Encoding Gene 16%
• Enhanced Virulence 16%
• Evolutionary Forces 16%
• Evolutionary History 33%
• Expression Difference 16%
• Functional Consequences 16%
• Gene Regulation 16%
• Genetic Background 16%
• Genetic Diversity 16%
• Group Comparison 16%
• Historical Loss 16%
• Housekeeping Genes 16%
• In the Wild 16%
• Large Collection 16%
• Mouse Model 50%
• Mouse Virulence 16%
• Natural Isolates 50%
• New Lineage 16%
• North America 16%
• Pathogenicity Variation 16%
• Polymorphism 16%
• Population Structure 16%
• Purifying Selection 16%
• Rhoptry 16%
• ROP18 100%
• Secretory Proteins 16%
• Selective Pressure 16%
• Sequence Polymorphism 16%
• Serine-threonine Kinase 16%
• Single Locus 100%
• Sweeping 16%
• Toxoplasma Gondii (T. gondii) 100%
• Upstream Regulatory Region 16%
• Very Virulent 16%
• Virulence 33%
• Virulence Determinants 16%

Immunology and Microbiology

• Allele 100%
• Diversifying Selection 20%
• Evolution 60%
• Genetic Background 20%
• Genetic Variability 20%
• Housekeeping Gene 20%
• Intron 20%
• Lineages 100%
• Mouse Model 60%
• Pathogenicity 20%
• Population Structure 20%
• Rhoptry 20%
• Secretory Protein 20%
• Serine 20%
• Threonine 20%
• Toxoplasma gondii 100%
• Upregulation 20%

Biochemistry, Genetics and Molecular Biology

• Allele 100%
• Diversifying Selection 20%
• Evolution 60%
• Genetic Background 20%
• Genetic Divergence 20%
• Housekeeping Gene 20%
• Intron 20%
• Kinase 20%
• Mouse Model 60%
• Phosphotransferase 20%
• Population Structure 20%
• Regulatory Element 20%
• Secretory Protein 20%
• Serine 20%
• Threonine 20%
• Toxoplasma gondii 100%
• Upregulation 20%