TY - JOUR
T1 - Selection and development of preclinical models in fracture-healing research
AU - O'Loughlin, Padhraig F.
AU - Morr, Simon
AU - Bogunovic, Ljiljana
AU - Kim, Abraham D.
AU - Park, Brian
AU - Lane, Joseph M.
PY - 2008/2
Y1 - 2008/2
N2 - Animal fracture models have been extensively applied to preclinical research as a platform to identify and characterize normal and abnormal physiological processes and to develop specific maneuvers that alter the biology and biomechanics being examined. The choice of animal model employed in a study bears a direct relationship to the specific intervention being analyzed. The animal models employed should be described clearly, control-group data should be established, and reproducibility should be defined from experiment to experiment and from institution to institution so that quantitative and qualitative outcomes can be reliably compared and contrasted to other related studies.
AB - Animal fracture models have been extensively applied to preclinical research as a platform to identify and characterize normal and abnormal physiological processes and to develop specific maneuvers that alter the biology and biomechanics being examined. The choice of animal model employed in a study bears a direct relationship to the specific intervention being analyzed. The animal models employed should be described clearly, control-group data should be established, and reproducibility should be defined from experiment to experiment and from institution to institution so that quantitative and qualitative outcomes can be reliably compared and contrasted to other related studies.
UR - http://www.scopus.com/inward/record.url?scp=40149090336&partnerID=8YFLogxK
U2 - 10.2106/JBJS.G.01585
DO - 10.2106/JBJS.G.01585
M3 - Article
C2 - 18292361
AN - SCOPUS:40149090336
SN - 0021-9355
VL - 90
SP - 79
EP - 84
JO - Journal of Bone and Joint Surgery - Series A
JF - Journal of Bone and Joint Surgery - Series A
IS - SUPPL. 1
ER -