Segregation analysis of the NIMH collaborative study. Family data on bipolar disorder

Pak C. Sham; Newton E. Morton; John P. Rice

doi:10.1097/00041444-199203000-00002

Segregation analysis of the NIMH collaborative study. Family data on bipolar disorder

Pak C. Sham, Newton E. Morton, John P. Rice

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25 Scopus citations

Abstract

Expanded analyses of the NIMH Collaborative Study family data on bipolar disorder showed that an earlier suggestion of non-Mendelian transmission was dependent on the definition of the liability indicator. When an appropriate liability indicator was used. polygenic and generalised single major locus models were almost equally compatible with the data.

Original language	English
Pages (from-to)	175-184
Number of pages	10
Journal	Psychiatric genetics
Volume	2
Issue number	3
DOIs	https://doi.org/10.1097/00041444-199203000-00002
State	Published - Mar 1991

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title = "Segregation analysis of the NIMH collaborative study. Family data on bipolar disorder",

abstract = "Expanded analyses of the NIMH Collaborative Study family data on bipolar disorder showed that an earlier suggestion of non-Mendelian transmission was dependent on the definition of the liability indicator. When an appropriate liability indicator was used. polygenic and generalised single major locus models were almost equally compatible with the data.",

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Segregation analysis of the NIMH collaborative study. Family data on bipolar disorder

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