Segregation analysis of the NIMH collaborative study. Family data on bipolar disorder

Pak C. Sham, Newton E. Morton, John P. Rice

Research output: Contribution to journalArticle

20 Scopus citations

Abstract

Expanded analyses of the NIMH Collaborative Study family data on bipolar disorder showed that an earlier suggestion of non-Mendelian transmission was dependent on the definition of the liability indicator. When an appropriate liability indicator was used. polygenic and generalised single major locus models were almost equally compatible with the data.

Original languageEnglish
Pages (from-to)175-184
Number of pages10
JournalPsychiatric genetics
Volume2
Issue number3
DOIs
StatePublished - Mar 1991

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