TY - JOUR
T1 - Segmental disorders of the nephron
T2 - Histopathological and imaging perspective
AU - Prasad, Srinivasa R.
AU - Narra, V. R.
AU - Shah, R.
AU - Humphrey, P. A.
AU - Jagirdar, J.
AU - Catena, J. R.
AU - Dalrymple, N. C.
AU - Siegel, C. L.
PY - 2007/8
Y1 - 2007/8
N2 - Recent advances in molecular genetics and immunocytochemistry have clarified the cell of origin in many renal disorders. Several renal disorders are thought to involve specific segments of the nephron. Renin-secreting tumours arise from juxtaglomerular cells. Clear cell and papillary renal cell carcinoma (RCC) recapitulate the epithelium of the proximal tubules. Oncocytoma and chromophobe RCC differentiate towards Type A and Type B intercalated cells of the cortical collecting duct, respectively. Medullary collecting ducts are the target sites for the development of autosomal recessive polycystic kidney disease, collecting duct carcinoma and medullary carcinoma. Renal papillae are susceptible to unique changes such as necrosis or papillitis. The purpose of our article is threefold: to illustrate the imaging findings of renal disorders that show segmental involvement of the nephron, to describe proximal and distal nephron disorders and to correlate imaging findings of some entities with histopathological features.
AB - Recent advances in molecular genetics and immunocytochemistry have clarified the cell of origin in many renal disorders. Several renal disorders are thought to involve specific segments of the nephron. Renin-secreting tumours arise from juxtaglomerular cells. Clear cell and papillary renal cell carcinoma (RCC) recapitulate the epithelium of the proximal tubules. Oncocytoma and chromophobe RCC differentiate towards Type A and Type B intercalated cells of the cortical collecting duct, respectively. Medullary collecting ducts are the target sites for the development of autosomal recessive polycystic kidney disease, collecting duct carcinoma and medullary carcinoma. Renal papillae are susceptible to unique changes such as necrosis or papillitis. The purpose of our article is threefold: to illustrate the imaging findings of renal disorders that show segmental involvement of the nephron, to describe proximal and distal nephron disorders and to correlate imaging findings of some entities with histopathological features.
UR - http://www.scopus.com/inward/record.url?scp=34948838260&partnerID=8YFLogxK
U2 - 10.1259/bjr/20129205
DO - 10.1259/bjr/20129205
M3 - Review article
C2 - 17621606
AN - SCOPUS:34948838260
SN - 0007-1285
VL - 80
SP - 593
EP - 602
JO - British Journal of Radiology
JF - British Journal of Radiology
IS - 956
ER -