SEER study of ablation versus partial nephrectomy in cT1A renal cell carcinoma

Minerva Zhou; Abigail Mills; Christopher Noda; Raja Ramaswamy; Olaguoke Akinwande

doi:10.2217/fon-2017-0678

SEER study of ablation versus partial nephrectomy in cT1A renal cell carcinoma

Minerva Zhou, Abigail Mills, Christopher Noda, Raja Ramaswamy, Olaguoke Akinwande

Department of Radiology

Research output: Contribution to journal › Article › peer-review

14 Scopus citations

Abstract

Aim: Compare ablation versus partial nephrectomy (PN) in T1A renal cell carcinoma (RCC) treatment, using the SEER database. Methods: Patients with diagnosed T1A RCC from 2004 to 2013 were identified. Propensity matching paired subjects with similar background variables. Kaplan-Meier and Cox proportional hazards regression were performed before and after matching. Results: Cohort included 4592 patients (809 ablation, 3783 PN). PN compared with ablation group had significantly increased overall survival (OS; 93.6% vs 81.9% 5-year survival; p < 0.0001) and cancer-specific survival (CSS; p < 0.0001). After matching (1222 pairs), PN group had significantly increased OS (91.0% vs 86.3% 5-year survival; p = 0.0457) but similar CSS (p = 0.4023). Conclusion: Ablation offers similar CSS but lower OS as PN for T1A RCC in this SEER database.

Original language	English
Pages (from-to)	1711-1719
Number of pages	9
Journal	Future Oncology
Volume	14
Issue number	17
DOIs	https://doi.org/10.2217/fon-2017-0678
State	Published - Jul 2018

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@article{8f449208bd884f0c8fa50543c7ce27e1,

title = "SEER study of ablation versus partial nephrectomy in cT1A renal cell carcinoma",

abstract = "Aim: Compare ablation versus partial nephrectomy (PN) in T1A renal cell carcinoma (RCC) treatment, using the SEER database. Methods: Patients with diagnosed T1A RCC from 2004 to 2013 were identified. Propensity matching paired subjects with similar background variables. Kaplan-Meier and Cox proportional hazards regression were performed before and after matching. Results: Cohort included 4592 patients (809 ablation, 3783 PN). PN compared with ablation group had significantly increased overall survival (OS; 93.6% vs 81.9% 5-year survival; p < 0.0001) and cancer-specific survival (CSS; p < 0.0001). After matching (1222 pairs), PN group had significantly increased OS (91.0% vs 86.3% 5-year survival; p = 0.0457) but similar CSS (p = 0.4023). Conclusion: Ablation offers similar CSS but lower OS as PN for T1A RCC in this SEER database.",

author = "Minerva Zhou and Abigail Mills and Christopher Noda and Raja Ramaswamy and Olaguoke Akinwande",

note = "Funding Information: This study was exempt from institutional review board approval and was completed in accordance with the National Cancer Institute SEER user agreement. Publisher Copyright: {\textcopyright} 2018 2018 Future Medicine Ltd.",

year = "2018",

month = jul,

doi = "10.2217/fon-2017-0678",

language = "English",

volume = "14",

pages = "1711--1719",

journal = "Future Oncology",

issn = "1479-6694",

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TY - JOUR

T1 - SEER study of ablation versus partial nephrectomy in cT1A renal cell carcinoma

AU - Zhou, Minerva

AU - Mills, Abigail

AU - Noda, Christopher

AU - Ramaswamy, Raja

AU - Akinwande, Olaguoke

N1 - Funding Information: This study was exempt from institutional review board approval and was completed in accordance with the National Cancer Institute SEER user agreement. Publisher Copyright: © 2018 2018 Future Medicine Ltd.

PY - 2018/7

Y1 - 2018/7

N2 - Aim: Compare ablation versus partial nephrectomy (PN) in T1A renal cell carcinoma (RCC) treatment, using the SEER database. Methods: Patients with diagnosed T1A RCC from 2004 to 2013 were identified. Propensity matching paired subjects with similar background variables. Kaplan-Meier and Cox proportional hazards regression were performed before and after matching. Results: Cohort included 4592 patients (809 ablation, 3783 PN). PN compared with ablation group had significantly increased overall survival (OS; 93.6% vs 81.9% 5-year survival; p < 0.0001) and cancer-specific survival (CSS; p < 0.0001). After matching (1222 pairs), PN group had significantly increased OS (91.0% vs 86.3% 5-year survival; p = 0.0457) but similar CSS (p = 0.4023). Conclusion: Ablation offers similar CSS but lower OS as PN for T1A RCC in this SEER database.

AB - Aim: Compare ablation versus partial nephrectomy (PN) in T1A renal cell carcinoma (RCC) treatment, using the SEER database. Methods: Patients with diagnosed T1A RCC from 2004 to 2013 were identified. Propensity matching paired subjects with similar background variables. Kaplan-Meier and Cox proportional hazards regression were performed before and after matching. Results: Cohort included 4592 patients (809 ablation, 3783 PN). PN compared with ablation group had significantly increased overall survival (OS; 93.6% vs 81.9% 5-year survival; p < 0.0001) and cancer-specific survival (CSS; p < 0.0001). After matching (1222 pairs), PN group had significantly increased OS (91.0% vs 86.3% 5-year survival; p = 0.0457) but similar CSS (p = 0.4023). Conclusion: Ablation offers similar CSS but lower OS as PN for T1A RCC in this SEER database.

UR - http://www.scopus.com/inward/record.url?scp=85050038309&partnerID=8YFLogxK

U2 - 10.2217/fon-2017-0678

DO - 10.2217/fon-2017-0678

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SN - 1479-6694

VL - 14

SP - 1711

EP - 1719

JO - Future Oncology

JF - Future Oncology

IS - 17

ER -

SEER study of ablation versus partial nephrectomy in cT1A renal cell carcinoma

Abstract

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