The presence of retinal vasculopathy in the absence of typical predisposing factors should suggest a possible underlying hematologic abnormality. In such cases, a systemic investigation may reveal a potentially fatal hypercoagulability or hyperviscosity syndrome. Retinal vein occlusion is the most commonly encountered ophthalmic finding in such syndromes; however, abnormalities of the arterial system, the choroid, and the macula are also possible. Visual symptoms may be the only manifestation of the underlying process, making timely diagnosis by the ophthalmologist critical for both treatment and thrombotic prophylaxis. Moreover, as newer ophthalmic diagnostic technologies arise, there is an increasingly important role for eye physicians in the management of such syndromes.

Original languageEnglish
Pages (from-to)236-247
Number of pages12
JournalSurvey of ophthalmology
Issue number2
StatePublished - Mar 1 2016


  • Factor V Leiden
  • Hyperhomocysteinemia
  • Indocyanine green angiography
  • Lymphoplasmacytic leukemia
  • Macular edema
  • Polycythemia
  • Prothrombin G20210A
  • Retinal vein occlusion
  • Serous choroidal detachment


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