Sedative and electroencephalographic actions of erythro-9-(2-hydroxy-3-nonyl)-adenine (EHNA): Relationship to inhibition of brain adenosine deaminase

Wallace B. Mendelson; Alice Kuruvilla; Thomas Watlington; Kevin Goehl; Steven M. Paul; Phil Skolnick

doi:10.1007/BF00427798

Sedative and electroencephalographic actions of erythro-9-(2-hydroxy-3-nonyl)-adenine (EHNA): Relationship to inhibition of brain adenosine deaminase

Wallace B. Mendelson
, Alice Kuruvilla
, Thomas Watlington
, Kevin Goehl
, Steven M. Paul
, Phil Skolnick

School of Medicine

Research output: Contribution to journal › Article › peer-review

23 Scopus citations

Abstract

Parenteral administration of the adenosine deaminase (ADA) inhibitor erythro-9-(2-hydroxy-3-nonyl)-adenine (EHNA) results in a profound decrease in spontaneous motor activity in mice and rats. The inhibition of cortical ADA activity measured ex vivo parallels the decrease in spontaneous motor activity in a time-dependent manner. Nonetheless, a marked reduction in electroencephalographically defined sleep was observed in rats during a period when both spontaneous motor activity and ADA activity were profoundly inhibited. These data suggest that EHNA produces in rats a state of 'quiescent waking', which may be related to the observed inhibition of brain ADA activity.

Original language	English
Pages (from-to)	126-129
Number of pages	4
Journal	Psychopharmacology
Volume	79
Issue number	2-3
DOIs	https://doi.org/10.1007/BF00427798
State	Published - Feb 1 1983

Keywords

Adenosine deaminase
Erythro-9-(2-hydroxy-3-nonyl)-adenine
Sleep
Spontaneous motor activity

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10.1007/BF00427798

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title = "Sedative and electroencephalographic actions of erythro-9-(2-hydroxy-3-nonyl)-adenine (EHNA): Relationship to inhibition of brain adenosine deaminase",

abstract = "Parenteral administration of the adenosine deaminase (ADA) inhibitor erythro-9-(2-hydroxy-3-nonyl)-adenine (EHNA) results in a profound decrease in spontaneous motor activity in mice and rats. The inhibition of cortical ADA activity measured ex vivo parallels the decrease in spontaneous motor activity in a time-dependent manner. Nonetheless, a marked reduction in electroencephalographically defined sleep was observed in rats during a period when both spontaneous motor activity and ADA activity were profoundly inhibited. These data suggest that EHNA produces in rats a state of 'quiescent waking', which may be related to the observed inhibition of brain ADA activity.",

keywords = "Adenosine deaminase, Erythro-9-(2-hydroxy-3-nonyl)-adenine, Sleep, Spontaneous motor activity",

author = "Mendelson, \{Wallace B.\} and Alice Kuruvilla and Thomas Watlington and Kevin Goehl and Paul, \{Steven M.\} and Phil Skolnick",

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T1 - Sedative and electroencephalographic actions of erythro-9-(2-hydroxy-3-nonyl)-adenine (EHNA)

T2 - Relationship to inhibition of brain adenosine deaminase

AU - Mendelson, Wallace B.

AU - Kuruvilla, Alice

AU - Watlington, Thomas

AU - Goehl, Kevin

AU - Paul, Steven M.

AU - Skolnick, Phil

PY - 1983/2/1

Y1 - 1983/2/1

N2 - Parenteral administration of the adenosine deaminase (ADA) inhibitor erythro-9-(2-hydroxy-3-nonyl)-adenine (EHNA) results in a profound decrease in spontaneous motor activity in mice and rats. The inhibition of cortical ADA activity measured ex vivo parallels the decrease in spontaneous motor activity in a time-dependent manner. Nonetheless, a marked reduction in electroencephalographically defined sleep was observed in rats during a period when both spontaneous motor activity and ADA activity were profoundly inhibited. These data suggest that EHNA produces in rats a state of 'quiescent waking', which may be related to the observed inhibition of brain ADA activity.

AB - Parenteral administration of the adenosine deaminase (ADA) inhibitor erythro-9-(2-hydroxy-3-nonyl)-adenine (EHNA) results in a profound decrease in spontaneous motor activity in mice and rats. The inhibition of cortical ADA activity measured ex vivo parallels the decrease in spontaneous motor activity in a time-dependent manner. Nonetheless, a marked reduction in electroencephalographically defined sleep was observed in rats during a period when both spontaneous motor activity and ADA activity were profoundly inhibited. These data suggest that EHNA produces in rats a state of 'quiescent waking', which may be related to the observed inhibition of brain ADA activity.

KW - Adenosine deaminase

KW - Erythro-9-(2-hydroxy-3-nonyl)-adenine

KW - Sleep

KW - Spontaneous motor activity

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SN - 0033-3158

VL - 79

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IS - 2-3

ER -

Sedative and electroencephalographic actions of erythro-9-(2-hydroxy-3-nonyl)-adenine (EHNA): Relationship to inhibition of brain adenosine deaminase

Abstract

Keywords

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