Sedative and electroencephalographic actions of erythro-9-(2-hydroxy-3-nonyl)-adenine (EHNA): Relationship to inhibition of brain adenosine deaminase

Wallace B. Mendelson, Alice Kuruvilla, Thomas Watlington, Kevin Goehl, Steven M. Paul, Phil Skolnick

Research output: Contribution to journalArticle

20 Scopus citations

Abstract

Parenteral administration of the adenosine deaminase (ADA) inhibitor erythro-9-(2-hydroxy-3-nonyl)-adenine (EHNA) results in a profound decrease in spontaneous motor activity in mice and rats. The inhibition of cortical ADA activity measured ex vivo parallels the decrease in spontaneous motor activity in a time-dependent manner. Nonetheless, a marked reduction in electroencephalographically defined sleep was observed in rats during a period when both spontaneous motor activity and ADA activity were profoundly inhibited. These data suggest that EHNA produces in rats a state of 'quiescent waking', which may be related to the observed inhibition of brain ADA activity.

Original languageEnglish
Pages (from-to)126-129
Number of pages4
JournalPsychopharmacology
Volume79
Issue number2-3
DOIs
StatePublished - Feb 1 1983

Keywords

  • Adenosine deaminase
  • Erythro-9-(2-hydroxy-3-nonyl)-adenine
  • Sleep
  • Spontaneous motor activity

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