TY - JOUR
T1 - Sedation versus General Anesthesia for Tracheal Intubation in Children with Difficult Airways
T2 - A Cohort Study from the Pediatric Difficult Intubation Registry
AU - PeDI Collaborative
AU - Sequera-Ramos, Luis
AU - Laverriere, Elizabeth K.
AU - Garcia-Marcinkiewicz, Annery G.
AU - Zhang, Bingqing
AU - Kovatsis, Pete G.
AU - Fiadjoe, John E.
AU - Lardner, David
AU - Von Ungern-Sternberg, Britta S.
AU - Sommerfield, David
AU - Holmes, Chris
AU - Sabato, Stefano
AU - Ravula, Niroop
AU - Jette, Christine
AU - Mireles, Sam
AU - Matava, Clyde
AU - Whyte, Simon
AU - Vega, Eduardo
AU - Yang, Lei
AU - Echeverry-Marin, Piedad
AU - Pérez-Pradilla, Carolina
AU - Jagannathan, Narasimhan
AU - Burjek, Nicholas E.
AU - Polaner, David
AU - Starker, Elizabeth
AU - Szolnoki, Judit
AU - Brooks-Peterson, Melissa
AU - Lee, Angela
AU - Heitmiller, Eugenie
AU - Rehman, Mohamed
AU - Fernandez, Allison
AU - Meserve, Jonathan
AU - Lord, Charles
AU - McCloskey, John
AU - Dalesio, Nicholas
AU - Koka, Rahul
AU - Greenberg, Robert
AU - Park, Raymond
AU - Peyton, James
AU - Stein, Mary Lyn
AU - Egbuta, Chinyere
AU - Flynn, Stephen
AU - Bhattacharya, Somaletha
AU - Reynolds, Paul
AU - Lewis, Ian
AU - Haydar, Bishr
AU - Sarmiento, Lina
AU - Richtsfeld, Martina
AU - Belani, Kumar
AU - Robertson, Sara
AU - Sathyamoorthy, Madhankumar
AU - Schrock, Charles
AU - De Graaff, Jurgen C.
AU - Soneru, Codruta
AU - Singh, Neeta
AU - Chiao, Franklin
AU - Taicher, Brad
AU - Templeton, Thomas
AU - Castro, Pilar
AU - Perez, N. Ricardo Riveros
AU - Raman, Vidya T.
AU - Beltran, Ralph
AU - Bhalla, Tarun
AU - Bruins, Benjamin B.
AU - Stricker, Paul
AU - Lockman, Justin L.
AU - Struyk, Brian
AU - Ward, Christopher
AU - Nishisaki, Akira
AU - Kodavatiganti, Ramesh
AU - Guris, Rodrigo J.Daly
AU - Teen, Mark S.
AU - Marín, Piedad C.Echeverry
AU - Watkins, Scott
AU - Crockett, Christy
AU - Moore, John
AU - Goldfarb, Tally
AU - Olomu, Patrick
AU - Szmuk, Peter
AU - Hopkins, Paul
AU - Glover, Chris
AU - Nguyen, Kim
AU - Shaw, Thomas L.
AU - Olutoye, Olutoyin
AU - Jain, Ranu
AU - Matuszczak, Maria
AU - Hunyady, Agnes
AU - Bosenberg, Adrian
AU - Tham, See
AU - Low, Daniel
AU - Bilen-Rosas, Guelay
AU - Fehr, James
AU - Lee, Lisa K.
AU - Ayad, Ihab
AU - Patel, Roshan
AU - Gooden, Cheryl
N1 - Publisher Copyright:
© 2022 Lippincott Williams and Wilkins. All rights reserved.
PY - 2022/10/1
Y1 - 2022/10/1
N2 - Background: Sedated and awake tracheal intubation approaches are considered safest in adults with difficult airways, but little is known about the outcomes of sedated intubations in children. The primary aim of this study was to compare the first-attempt success rate of tracheal intubation during sedated tracheal intubation versus tracheal intubation under general anesthesia. The hypothesis was that sedated intubation would be associated with a lower first-attempt success rate and more complications than general anesthesia. Methods: This study used data from an international observational registry, the Pediatric Difficult Intubation Registry, which prospectively collects data about tracheal intubation in children with difficult airways. The use of sedation versus general anesthesia for tracheal intubation were compared. The primary outcome was the first-attempt success of tracheal intubation. Secondary outcomes included the number of intubation attempts and nonsevere and severe complications. Propensity score matching was used with a matching ratio up to 1:15 to reduce bias due to measured confounders. Results: Between 2017 and 2020, 34 hospitals submitted 1,839 anticipated difficult airway cases that met inclusion criteria for the study. Of these, 75 patients received sedation, and 1,764 patients received general anesthesia. Propensity score matching resulted in 58 patients in the sedation group and 522 patients in the general anesthesia group. The rate of first-attempt success of tracheal intubation was 28 of 58 (48.3%) in the sedation group and 250 of 522 (47.9%) in the general anesthesia group (odds ratio, 1.06; 95% CI, 0.60 to 1.87; P = 0.846). The median number of intubations attempts was 2 (interquartile range, 1 to 3) in the sedation group and 2 (interquartile range, 1, 2) in the general anesthesia group. The general anesthesia group had 6 of 522 (1.1%) intubation failures versus 0 of 58 in the sedation group. However, 16 of 58 (27.6%) sedation cases had to be converted to general anesthesia for successful tracheal intubation. Complications were similar between the groups, and the rate of severe complications was low. Conclusions: Sedation and general anesthesia had a similar rate of first-attempt success of tracheal intubation in children with difficult airways; however, 27.6% of the sedation cases needed to be converted to general anesthesia to complete tracheal intubation. Complications overall were similar between the groups, and the rate of severe complications was low.
AB - Background: Sedated and awake tracheal intubation approaches are considered safest in adults with difficult airways, but little is known about the outcomes of sedated intubations in children. The primary aim of this study was to compare the first-attempt success rate of tracheal intubation during sedated tracheal intubation versus tracheal intubation under general anesthesia. The hypothesis was that sedated intubation would be associated with a lower first-attempt success rate and more complications than general anesthesia. Methods: This study used data from an international observational registry, the Pediatric Difficult Intubation Registry, which prospectively collects data about tracheal intubation in children with difficult airways. The use of sedation versus general anesthesia for tracheal intubation were compared. The primary outcome was the first-attempt success of tracheal intubation. Secondary outcomes included the number of intubation attempts and nonsevere and severe complications. Propensity score matching was used with a matching ratio up to 1:15 to reduce bias due to measured confounders. Results: Between 2017 and 2020, 34 hospitals submitted 1,839 anticipated difficult airway cases that met inclusion criteria for the study. Of these, 75 patients received sedation, and 1,764 patients received general anesthesia. Propensity score matching resulted in 58 patients in the sedation group and 522 patients in the general anesthesia group. The rate of first-attempt success of tracheal intubation was 28 of 58 (48.3%) in the sedation group and 250 of 522 (47.9%) in the general anesthesia group (odds ratio, 1.06; 95% CI, 0.60 to 1.87; P = 0.846). The median number of intubations attempts was 2 (interquartile range, 1 to 3) in the sedation group and 2 (interquartile range, 1, 2) in the general anesthesia group. The general anesthesia group had 6 of 522 (1.1%) intubation failures versus 0 of 58 in the sedation group. However, 16 of 58 (27.6%) sedation cases had to be converted to general anesthesia for successful tracheal intubation. Complications were similar between the groups, and the rate of severe complications was low. Conclusions: Sedation and general anesthesia had a similar rate of first-attempt success of tracheal intubation in children with difficult airways; however, 27.6% of the sedation cases needed to be converted to general anesthesia to complete tracheal intubation. Complications overall were similar between the groups, and the rate of severe complications was low.
UR - http://www.scopus.com/inward/record.url?scp=85138490107&partnerID=8YFLogxK
U2 - 10.1097/ALN.0000000000004353
DO - 10.1097/ALN.0000000000004353
M3 - Article
C2 - 35950814
AN - SCOPUS:85138490107
SN - 0003-3022
VL - 137
SP - 418
EP - 433
JO - Anesthesiology
JF - Anesthesiology
IS - 4
ER -