Secondary sclerosing cholangitis: mimics of primary sclerosing cholangitis

Daniel R. Ludwig, Mark A. Anderson, Malak Itani, Kedar G. Sharbidre, Neeraj Lalwani, Raj M. Paspulati

Research output: Contribution to journalReview articlepeer-review

2 Scopus citations


Sclerosing cholangitis is a chronic cholestatic disease characterized by stricturing, beading, and obliterative fibrosis of the bile ducts. Sclerosing cholangitis is considered primary (PSC) if no underlying etiology is identified or secondary (SSC) if related to another identifiable cause. In this article, we will review the clinical features, pathogenesis, diagnosis, and imaging findings of PSC and SSC, with an emphasis on features that may aid in the distinction of these entities. We will also discuss various etiologies of SSC including recurrent pyogenic cholangitis, other infectious etiologies, ischemic damage, toxic insults, and immunologic, congenital, and miscellaneous causes, highlighting the unique imaging findings and clinical context of each diagnosis. Graphical abstract: [Figure not available: see fulltext.]

Original languageEnglish
Pages (from-to)151-165
Number of pages15
JournalAbdominal Radiology
Issue number1
StatePublished - Jan 2023


  • AIDS cholangiopathy
  • IgG4-related sclerosing cholangitis
  • Ischemic cholangiopathy
  • Recurrent pyogenic cholangitis
  • Secondary sclerosing cholangitis
  • Toxic cholangiopathy


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