Searching for the Noninvasive Biomarker Holy Grail: Are Urine Proteomics the Answer?

Joachim Voss, Young Ah Goo, Kevin Cain, Nancy Woods, Monica Jarrett, Lynne Smith, Robert Shulman, Margaret Heitkemper

Research output: Contribution to journalReview articlepeer-review

13 Scopus citations


Recently, biobehavioral nursing scientists have focused their attention on the search for biomarkers or biological signatures to identify patients at risk for various health problems and poor disease outcomes. In response to the national impetus for biomarker discovery, the measurement of biological fluids and tissues has become increasingly sophisticated. Urine proteomics, in particular, may hold great promise for biobehavioral focused nursing scientists for examination of symptom-and syndrome-related research questions. Urine proteins are easily accessible secreted proteins that provide direct and indirect windows into bodily functions. Advances in proteomics and biomarker discovery provide new opportunities to conduct research studies with banked and fresh urine to benefit diagnosis, prognosis, and evaluation of outcomes in various disease populations. This article provides a review of proteomics and a rationale for utilizing urine proteomics in biobehavioral research. It addresses as well some of the challenges involved in data collection and sample preparation.

Original languageEnglish
Pages (from-to)235-242
Number of pages8
JournalBiological Research for Nursing
Issue number3
StatePublished - Jul 2011


  • irritable bowel syndrome
  • mass spectrometry
  • proteomics
  • urine


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