TY - JOUR
T1 - Screening endoscopy and risk of colorectal cancer in United States men
AU - Kavanagh, Anne M.
AU - Giovannucci, Edward L.
AU - Fuchs, Charles S.
AU - Colditz, Graham A.
N1 - Funding Information:
Drs Giovannucci, Fuchs, and Colditz are with the Channing Laboratory, Department of Medicine, Brigham and Women's Hospital and Harvard Medical School, Boston, MA (USA). Drs Colditz and Giovannucci are also affiliated with the Harvard School of Public Health, Boston, MA. Dr Kavanagh is affiliated with the Anti-Cancer Council of Victoria, Australia. Address correspondence to Dr Colditz, Channing Laboratory, 181 Longwood Avenue, 3rd Floor, Boston, MA 02115, USA. This study was supported by research grant HS 07038. Dr Kavanagh is supported by a Public Health and Research Development Fellowship from the National Health and Medical Research Council of Australia.
PY - 1998
Y1 - 1998
N2 - Objectives: The purpose of this study was to describe the effect of screening endoscopy (sigmoidoscopy or colonoscopy) on colorectal cancer incidence and mortality. Methods: We used data from a prospective cohort study of 24,744 men aged 40 to 75 years in 1986, free from cancer and colon polyps, followed until 1994. The outcomes are diagnosis of colorectal cancer and death from colorectal cancer. Results: Screening endoscopy in 1986-87 was associated with a lower risk of all colorectal cancer (multivariate relative risk [RR] = 0.58, 95 percent confidence interval [CI] =0.36-0.96); cancer in the distal colon or rectum (multivariate RR = 0.40, CI = 0.19-0.84); Dukes stage A and B (multivariate RR = 0.66, CI = 0.35-1.25); and Dukes stage C and D (multivariate RR = 0.50, CI = 0.20-1.26) colorectal cancer; and death from colorectal cancer (multivariate RR = 0.56, CI = 0.20-1.60), after adjusting for age and a wide range of colon cancer risk factors. Screening endoscopy in 1988-87 appeared to provide strong protection against distal stage C and D cancers (age-adjusted RR = 0.16, CI = 0.02-1.23) but no protection against proximal stage C and D cancers (age-adjusted RR = 0.96, CI = 0.32-2.91). Conclusions: This study provides strong evidence for a protective effect of screening sigmoidoscopy on colorectal cancer incidence and mortality and supports recommendations for screening sigmoidoscopy as an approach to colon cancer prevention.
AB - Objectives: The purpose of this study was to describe the effect of screening endoscopy (sigmoidoscopy or colonoscopy) on colorectal cancer incidence and mortality. Methods: We used data from a prospective cohort study of 24,744 men aged 40 to 75 years in 1986, free from cancer and colon polyps, followed until 1994. The outcomes are diagnosis of colorectal cancer and death from colorectal cancer. Results: Screening endoscopy in 1986-87 was associated with a lower risk of all colorectal cancer (multivariate relative risk [RR] = 0.58, 95 percent confidence interval [CI] =0.36-0.96); cancer in the distal colon or rectum (multivariate RR = 0.40, CI = 0.19-0.84); Dukes stage A and B (multivariate RR = 0.66, CI = 0.35-1.25); and Dukes stage C and D (multivariate RR = 0.50, CI = 0.20-1.26) colorectal cancer; and death from colorectal cancer (multivariate RR = 0.56, CI = 0.20-1.60), after adjusting for age and a wide range of colon cancer risk factors. Screening endoscopy in 1988-87 appeared to provide strong protection against distal stage C and D cancers (age-adjusted RR = 0.16, CI = 0.02-1.23) but no protection against proximal stage C and D cancers (age-adjusted RR = 0.96, CI = 0.32-2.91). Conclusions: This study provides strong evidence for a protective effect of screening sigmoidoscopy on colorectal cancer incidence and mortality and supports recommendations for screening sigmoidoscopy as an approach to colon cancer prevention.
KW - Colorectal cancer
KW - Men
KW - Screening endoscopy
KW - United States
UR - https://www.scopus.com/pages/publications/0031663533
U2 - 10.1023/A:1008884021049
DO - 10.1023/A:1008884021049
M3 - Article
C2 - 9794179
AN - SCOPUS:0031663533
SN - 0957-5243
VL - 9
SP - 455
EP - 462
JO - Cancer Causes and Control
JF - Cancer Causes and Control
IS - 4
ER -