Screening and treating for primary cytomegalovirus infection in pregnancy: where do we stand? A decision-analytic and economic analysis

Alison G. Cahill, Anthony O. Odibo, David M. Stamilio, George A. Macones

Research output: Contribution to journalArticle

39 Scopus citations

Abstract

Objective: To estimate which 1 of 3 screening strategies for primary maternal cytomegalovirus infection, with intention to treat with hyperimmune globulin, is most cost-effective. Study Design: A decision-analytic and cost-effectiveness model was constructed for pregnant women, comparing 3 strategies screening for primary maternal cytomegalovirus infection with intention to treat with cytomegalovirus-intravenous immune globulin: (1) serum screen all pregnant women, (2) serum screen women with risk factors for primary cytomegalovirus, (3) serum screen women with suspicious sonographic findings. Probability, use (or value), and cost estimates were derived from published literature. Results: Universal screening for primary maternal cytomegalovirus was the preferred and most cost-effective strategy. However, if treatment with cytomegalovirus-intravenous immune globulin achieved less than a 47% reduction (relative risk, 0.53) in clinical disease, universal screening would no longer be cost-effective. Conclusion: Universal screening for primary maternal cytomegalovirus infection is cost-effective based on available evidence, highlighting the urgent need for additional study evaluating the efficacy of cytomegalovirus-intravenous immune globulin to prevent congenital cytomegalovirus.

Original languageEnglish
Pages (from-to)466.e1-466.e7
JournalAmerican journal of obstetrics and gynecology
Volume201
Issue number5
DOIs
StatePublished - Nov 2009

Keywords

  • congenital CMV
  • cytomegalovirus
  • pregnancy
  • primary CMV

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