TY - JOUR
T1 - Scoliosis severity does not impact the risk of scoliosis in family members
AU - Rudnick, Samuel B.
AU - Zabriskie, Hannah
AU - Ho, Justin
AU - Gurnett, Christina A.
AU - Dobbs, Matthew B.
N1 - Funding Information:
The authors would like to acknowledge the patients who participated as well as Drs Lawrence Lenke, Keith Bridwell, Munish Gupta, Mike Kelly, and Scott Luhmann for contributing patients for this study. Research reported in this publication was supported by the National Institute of Arthritis and Musculoskeletal and Skin Diseases of the National Institute of Health under award number (R01 AR067715-01) and the Eunice Kennedy Shriver National Institute of Child Health and Human Development of the National Institutes of Health under Award Number U54 HD087011 to the Intellectual and Developmental Disabilities Research Center at Washington University. Research reported in this publication was supported by the Washington University Institute of Clinical and Translational Sciences grant UL1 TR000448 from the National Center for Advancing Translational Sciences (NCATS) of the National Institutes of Health (NIH). The content is solely the responsibility of the authors and does not necessarily represent the official views of the National Institutes of Health.
Publisher Copyright:
© 2018 Wolters Kluwer Health, Inc. All rights reserved.
PY - 2018
Y1 - 2018
N2 - Does scoliosis severity increase scoliosis risk or severity in relatives? In a cohort of 1257 severe idiopathic scoliosis patients, the percentage with at least one affected relative was compared across the categories of patient sex, major curve severity (Cobb angle), and treatment method. In total, 138 (11%) of 1257 patients had at least one affected first-degree relative and 59 (5%) had at least one affected second-degree relative. As expected, males were more likely to have affected first-degree relatives than females (18 vs. 10% with a risk difference of-0.0864) [95% confidence interval (CI):-0.14 to-0.03; P=0.0002]. However, the major curve severity of the patient (<25°, 25°-49°, and ≥50°) did not impact the prevalence of having at least one affected relative (P=0.69). Surgically treated patients had no greater risk than nonsurgically treated patients of having either an affected relative or a surgically treated relative [11 vs. 11% (odds ratio: 0.912; 95% CI: 0.640-1.299, P=0.61), 6 vs. 5% (OR: 0.788; 95% CI: 0.485-1.280, P=0.34), respectively]. Therefore, our data suggest that scoliosis severity does not independently influence the risk of either scoliosis or its severity in family members.
AB - Does scoliosis severity increase scoliosis risk or severity in relatives? In a cohort of 1257 severe idiopathic scoliosis patients, the percentage with at least one affected relative was compared across the categories of patient sex, major curve severity (Cobb angle), and treatment method. In total, 138 (11%) of 1257 patients had at least one affected first-degree relative and 59 (5%) had at least one affected second-degree relative. As expected, males were more likely to have affected first-degree relatives than females (18 vs. 10% with a risk difference of-0.0864) [95% confidence interval (CI):-0.14 to-0.03; P=0.0002]. However, the major curve severity of the patient (<25°, 25°-49°, and ≥50°) did not impact the prevalence of having at least one affected relative (P=0.69). Surgically treated patients had no greater risk than nonsurgically treated patients of having either an affected relative or a surgically treated relative [11 vs. 11% (odds ratio: 0.912; 95% CI: 0.640-1.299, P=0.61), 6 vs. 5% (OR: 0.788; 95% CI: 0.485-1.280, P=0.34), respectively]. Therefore, our data suggest that scoliosis severity does not independently influence the risk of either scoliosis or its severity in family members.
KW - adolescent
KW - familial
KW - fusion
KW - juvenile
KW - scoliosis
UR - http://www.scopus.com/inward/record.url?scp=85021111093&partnerID=8YFLogxK
U2 - 10.1097/BPB.0000000000000473
DO - 10.1097/BPB.0000000000000473
M3 - Article
C2 - 28628580
AN - SCOPUS:85021111093
VL - 27
SP - 147
EP - 151
JO - Journal of Pediatric Orthopaedics Part B
JF - Journal of Pediatric Orthopaedics Part B
SN - 1060-152X
IS - 2
ER -