SCMTR: A chloride-selective, membrane-anchored peptide channel that exhibits voltage gating

Paul H. Schlesinger, Riccardo Ferdani, Jun Liu, Jolanta Pajewska, Robert Pajewski, Mitsuyoshi Saito, Hossein Shabany, George W. Gokel

Research output: Contribution to journalArticle

121 Scopus citations

Abstract

The design, synthesis, and characterization of a synthetic chloride membrane transporter, SCMTR (synthetic chloride membrane transporter, "scimitar"), are presented. The compound [CH3(CH2)17]2NCOCH2OCH2CO-GGGPGGG-OBzl inserts rapidly into liposomes and planar lipid bilayers. SCMTR has a 1.3 ± 0.01 nS chloride diffusion pathway (>10:1 Cl/K selectivity). Evidence was also obtained for voltage gating behavior.

Original languageEnglish
Pages (from-to)1848-1849
Number of pages2
JournalJournal of the American Chemical Society
Volume124
Issue number9
DOIs
StatePublished - Mar 6 2002

Fingerprint Dive into the research topics of 'SCMTR: A chloride-selective, membrane-anchored peptide channel that exhibits voltage gating'. Together they form a unique fingerprint.

  • Cite this

    Schlesinger, P. H., Ferdani, R., Liu, J., Pajewska, J., Pajewski, R., Saito, M., Shabany, H., & Gokel, G. W. (2002). SCMTR: A chloride-selective, membrane-anchored peptide channel that exhibits voltage gating. Journal of the American Chemical Society, 124(9), 1848-1849. https://doi.org/10.1021/ja016784d