Sclerotic bone disorders

Sina Jasim, Robert Wermers, Daniel L. Hurley

Research output: Chapter in Book/Report/Conference proceedingChapterpeer-review


Sclerotic bone diseases are heterogenous group characterized by increased bone density as a result of bone-remodeling abnormalities. Osteosclerosis results from increased osteoblastic and/or decreased osteoclastic activity resulting in trabecular bone thickening and subsequent increase in skeletal mass. These disorders can be hereditary/genetic bone disorders or acquired secondary to systemic disease, metabolic, or environmental factors. It is extremely important to diagnose localized or generalized sclerotic bone disease and identify the culprit as, in many cases, it can be treatable. Subsequent follow-up depends in large part on the causative factor with the goal to prevent fractures and deformities. In this chapter, we will review some of the known causes of osteosclerosis with a focus on metabolic and acquired causes.

Original languageEnglish
Title of host publicationMetabolic Bone Diseases
Subtitle of host publicationA Case-Based Approach
PublisherSpringer International Publishing
Number of pages14
ISBN (Electronic)9783030036942
ISBN (Print)9783030036935
StatePublished - Jan 1 2019


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