Sclerotic bone disorders

Sina Jasim; Robert Wermers; Daniel L. Hurley

doi:10.1007/978-3-030-03694-2

Sclerotic bone disorders

Sina Jasim, Robert Wermers, Daniel L. Hurley

Research output: Chapter in Book/Report/Conference proceeding › Chapter › peer-review

Abstract

Sclerotic bone diseases are heterogenous group characterized by increased bone density as a result of bone-remodeling abnormalities. Osteosclerosis results from increased osteoblastic and/or decreased osteoclastic activity resulting in trabecular bone thickening and subsequent increase in skeletal mass. These disorders can be hereditary/genetic bone disorders or acquired secondary to systemic disease, metabolic, or environmental factors. It is extremely important to diagnose localized or generalized sclerotic bone disease and identify the culprit as, in many cases, it can be treatable. Subsequent follow-up depends in large part on the causative factor with the goal to prevent fractures and deformities. In this chapter, we will review some of the known causes of osteosclerosis with a focus on metabolic and acquired causes.

Original language	English
Title of host publication	Metabolic Bone Diseases
Subtitle of host publication	A Case-Based Approach
Publisher	Springer International Publishing
Pages	169-182
Number of pages	14
ISBN (Electronic)	9783030036942
ISBN (Print)	9783030036935
DOIs	https://doi.org/10.1007/978-3-030-03694-2
State	Published - Jan 1 2019

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N2 - Sclerotic bone diseases are heterogenous group characterized by increased bone density as a result of bone-remodeling abnormalities. Osteosclerosis results from increased osteoblastic and/or decreased osteoclastic activity resulting in trabecular bone thickening and subsequent increase in skeletal mass. These disorders can be hereditary/genetic bone disorders or acquired secondary to systemic disease, metabolic, or environmental factors. It is extremely important to diagnose localized or generalized sclerotic bone disease and identify the culprit as, in many cases, it can be treatable. Subsequent follow-up depends in large part on the causative factor with the goal to prevent fractures and deformities. In this chapter, we will review some of the known causes of osteosclerosis with a focus on metabolic and acquired causes.

AB - Sclerotic bone diseases are heterogenous group characterized by increased bone density as a result of bone-remodeling abnormalities. Osteosclerosis results from increased osteoblastic and/or decreased osteoclastic activity resulting in trabecular bone thickening and subsequent increase in skeletal mass. These disorders can be hereditary/genetic bone disorders or acquired secondary to systemic disease, metabolic, or environmental factors. It is extremely important to diagnose localized or generalized sclerotic bone disease and identify the culprit as, in many cases, it can be treatable. Subsequent follow-up depends in large part on the causative factor with the goal to prevent fractures and deformities. In this chapter, we will review some of the known causes of osteosclerosis with a focus on metabolic and acquired causes.

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Sclerotic bone disorders

Abstract

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