Sclerotic bone diseases are heterogenous group characterized by increased bone density as a result of bone-remodeling abnormalities. Osteosclerosis results from increased osteoblastic and/or decreased osteoclastic activity resulting in trabecular bone thickening and subsequent increase in skeletal mass. These disorders can be hereditary/genetic bone disorders or acquired secondary to systemic disease, metabolic, or environmental factors. It is extremely important to diagnose localized or generalized sclerotic bone disease and identify the culprit as, in many cases, it can be treatable. Subsequent follow-up depends in large part on the causative factor with the goal to prevent fractures and deformities. In this chapter, we will review some of the known causes of osteosclerosis with a focus on metabolic and acquired causes.
|Title of host publication||Metabolic Bone Diseases|
|Subtitle of host publication||A Case-Based Approach|
|Publisher||Springer International Publishing|
|Number of pages||14|
|State||Published - Jan 1 2019|