Scintigraphy with 111In-labeled autologous platelets in venous thromboembolism

H. H. Davis, B. A. Siegel, L. A. Sherman

Research output: Contribution to journalArticle

31 Scopus citations

Abstract

Scintigraphy with 111In-labeled autologous platelets was performed in 20 patients with suspected venous thrombosis and/or pulmonary embolism. The platelets accumulated in venous thrombi in 6 of 7 patients (86%) with positive findings on impedance plethysmography or contrast venography; all 6 were receiving intravenous heparin. In 11 patients with pulmonary embolism diagnosed by ventilation-perfusion imaging or pulmonary angiography, platelet scintigraphy showed embolic uptake only in the one patient not on full-dose heparin. These findings suggest that scintigraphy with 111In-platelets is a promising noninvasive technique for detection of deep venous thrombosis. Heparin does not appear to block localization of labeled platelets in venous thrombi, but may inhibit their adherence to pulmonary emboli.

Original languageEnglish
Pages (from-to)203-207
Number of pages5
JournalRadiology
Volume136
Issue number1
DOIs
StatePublished - Jan 1 1980

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