Scintigraphic detection of pulmonary embolism in patients with obstructive pulmonary disease

P. O. Alderson, D. R. Biello, K. G. Sacchariah, B. A. Siegel

Research output: Contribution to journalArticlepeer-review

49 Scopus citations


The 133Xe ventilation (V) studies, 99mTc perfusion (P) lung images, and pulmonary angiograms of 83 patients with obstructive pulmonary disease (OPD) and suspected pulmonary emboli (PE) were reviewed. Each patient had ventilation abnormalities suggesting OPD and at least one region showing matched V-P abnormalities. All angiograms were obtained within 72 hours of the V-P study and were reviewed independently. The overall sensitivity of V-P imaging for PE in this population was 0.83 and its specificity was 0.92. False-negative interpretations occurred in three of the 16 patients who showed ventilation abnormalities in more than 50% of their lung fields. In the 67 patients with ventilation abnormalities in ≤50% of their lung fields the sensitivity (0.95) and specificity (0.94) for detecting PE were high. V-P imaging is a reliable method for detecting PE in patients with regions of V-P match, if the ventilation abnormalities are limited in extent.

Original languageEnglish
Pages (from-to)661-666
Number of pages6
Issue number5
StatePublished - Dec 1 1981


Dive into the research topics of 'Scintigraphic detection of pulmonary embolism in patients with obstructive pulmonary disease'. Together they form a unique fingerprint.

Cite this