TY - JOUR
T1 - Science Signaling podcast
T2 - 21 April 2015
AU - Dorn, Gerald W.
AU - Song, Moshi
AU - VanHook, Annalisa M.
PY - 2015/4/21
Y1 - 2015/4/21
N2 - This Podcast features an interview with Gerald W. Dorn II and Moshi Song, authors of a Research Article that appears in the 21 April 2015 issue of Science Signaling, about how two related isoforms of protein kinase C (PKC) control growth of the heart in both developmental and pathological contexts. There are several isoforms of PKC, and these participate in many different signaling pathways that control diverse cellular processes. Based on how they are activated, PKCs are categorized into three groups: conventional, novel, and atypical. PKCδ and PKCε are closely related novel PKCs that have partially redundant functions in the heart. By removing both PKCδ and PKCε from cardiomyocytes, Song et al. found that these two related PKC isoforms normally limit heart growth both during development and in adult mice. Embryos lacking both PKCδ and PKCε had enlarged hearts, and adults lacking both PKCδ and PKCε exhibited greater cardiac hypertrophy in response to pressure overload. These results have implications for the clinical use of PKC inhibitors to treat cardiac disease and other diseases, such as cancer.
AB - This Podcast features an interview with Gerald W. Dorn II and Moshi Song, authors of a Research Article that appears in the 21 April 2015 issue of Science Signaling, about how two related isoforms of protein kinase C (PKC) control growth of the heart in both developmental and pathological contexts. There are several isoforms of PKC, and these participate in many different signaling pathways that control diverse cellular processes. Based on how they are activated, PKCs are categorized into three groups: conventional, novel, and atypical. PKCδ and PKCε are closely related novel PKCs that have partially redundant functions in the heart. By removing both PKCδ and PKCε from cardiomyocytes, Song et al. found that these two related PKC isoforms normally limit heart growth both during development and in adult mice. Embryos lacking both PKCδ and PKCε had enlarged hearts, and adults lacking both PKCδ and PKCε exhibited greater cardiac hypertrophy in response to pressure overload. These results have implications for the clinical use of PKC inhibitors to treat cardiac disease and other diseases, such as cancer.
KW - Cardiac hypertrophy
KW - Cardiomyocyte
KW - Embryonic heart development
KW - Heart disease
KW - Science Signaling
UR - http://www.scopus.com/inward/record.url?scp=84928182122&partnerID=8YFLogxK
U2 - 10.1126/scisignal.aab2834
DO - 10.1126/scisignal.aab2834
M3 - Article
AN - SCOPUS:84928182122
SN - 1945-0877
VL - 8
JO - Science signaling
JF - Science signaling
IS - 373
M1 - pc10
ER -