TY - GEN
T1 - Schizophrenia classification using working memory MEG ERD/ERS patterns
AU - Ince, Nuri F.
AU - Stephane, Massoud
AU - Tewfik, Ahmed H.
AU - Pellizzer, Giuseppe
AU - McClannahan, Kate
PY - 2007
Y1 - 2007
N2 - In this paper we investigate the use of event related desynchronization (ERD) and synchronization (ERS) patterns extracted from magnetoencephalogram (MEG) in a working memory task to discriminate between controls and patients with schizophrenia. In the experimental paradigm, sequential letters appearing on a screen are memorized by subjects. In one of two conditions the letters constituted a word. The ERD and ERS patterns are extracted in the theta, alpha, beta and gamma bands from 248 electrode locations covering the whole head. We noticed that most of the ERD patterns are localized on the left frontotemporal area in both word and nonword conditions in the late memorization stage. The beta band showed the most significant difference in this cortical area between controls and schizophrenia patients. By using a decision tree, 94.7% and 87.5% classification accuracy was obtained for controls and patients individually in both word and nonword conditions. Furthermore, we report that on the left frontotem poral lobe, the discrimination within the beta band between patients and controls in the word condition was higher than in the nonword condition. The higher discrimination within the word condition can be linked to the abnormalities in language processing in schizophrenia patients. Our results show that the ERD/ERS patterns extracted from MEG can be successfully used in patient-control discrimination with appropriate adjustment of spatial, spectral, temporal and functional process parameters.
AB - In this paper we investigate the use of event related desynchronization (ERD) and synchronization (ERS) patterns extracted from magnetoencephalogram (MEG) in a working memory task to discriminate between controls and patients with schizophrenia. In the experimental paradigm, sequential letters appearing on a screen are memorized by subjects. In one of two conditions the letters constituted a word. The ERD and ERS patterns are extracted in the theta, alpha, beta and gamma bands from 248 electrode locations covering the whole head. We noticed that most of the ERD patterns are localized on the left frontotemporal area in both word and nonword conditions in the late memorization stage. The beta band showed the most significant difference in this cortical area between controls and schizophrenia patients. By using a decision tree, 94.7% and 87.5% classification accuracy was obtained for controls and patients individually in both word and nonword conditions. Furthermore, we report that on the left frontotem poral lobe, the discrimination within the beta band between patients and controls in the word condition was higher than in the nonword condition. The higher discrimination within the word condition can be linked to the abnormalities in language processing in schizophrenia patients. Our results show that the ERD/ERS patterns extracted from MEG can be successfully used in patient-control discrimination with appropriate adjustment of spatial, spectral, temporal and functional process parameters.
UR - http://www.scopus.com/inward/record.url?scp=34548706510&partnerID=8YFLogxK
U2 - 10.1109/CNE.2007.369708
DO - 10.1109/CNE.2007.369708
M3 - Conference contribution
AN - SCOPUS:34548706510
SN - 1424407923
SN - 9781424407927
T3 - Proceedings of the 3rd International IEEE EMBS Conference on Neural Engineering
SP - 457
EP - 460
BT - Proceedings of the 3rd International IEEE EMBS Conference on Neural Engineering
T2 - 3rd International IEEE EMBS Conference on Neural Engineering
Y2 - 2 May 2007 through 5 May 2007
ER -