SCCA2-like serpins mediate genetic predisposition to skin tumors

Manuela Gariboldi, Bernard Peissel, Alessandra Fabbri, Anna Saran, Daniela Zaffaroni, F. Stefania Falvella, Monica Spinola, Jun ichi Tanuma, Simonetta Pazzaglia, Maria Teresa Mancuso, Andrea Maurichi, Cesare Bartoli, Sule Cataltepe, Gary A. Silverman, Silvana Pilotti, Yoshihide Hayashizaki, Yasushi Okazaki, Tommaso A. Dragani

Research output: Contribution to journalArticle

12 Scopus citations

Abstract

Reasons for early onset skin cancer are poorly understood. Microarray analysis revealed overexpression of the Scca2 gene in the 12-O-tetradecanoylphorbol-13-acetate-treated skin of Car-S mice, or line phenotypically selected for high susceptibility to two-stage skin carcinogenesis, as compared with 12-O-tetradecanoylphorbol-13-acetate-treated skin of Car-R mice, which is resistant. A human skin squamous cell carcinoma cell line (NCI-H520) transfected with mouse Scca2 or a related gene, Scca2-rs1, both expressed in the skin, showed significantly increased tumor growth as compared with controls when injected in nude mice. Immunohistochemical analysis of samples from two independent series of Italian and Korean patients with squamous cell carcinoma of the skin indicated a significant association between SCCA2 protein expression and younger age at tumor onset. These findings provide evidence that SCCA2-like serpins mediate genetic predisposition to skin cancer in a mouse model and in humans.

Original languageEnglish
Pages (from-to)1871-1875
Number of pages5
JournalCancer research
Volume63
Issue number8
StatePublished - Apr 15 2003
Externally publishedYes

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    Gariboldi, M., Peissel, B., Fabbri, A., Saran, A., Zaffaroni, D., Stefania Falvella, F., Spinola, M., Tanuma, J. I., Pazzaglia, S., Mancuso, M. T., Maurichi, A., Bartoli, C., Cataltepe, S., Silverman, G. A., Pilotti, S., Hayashizaki, Y., Okazaki, Y., & Dragani, T. A. (2003). SCCA2-like serpins mediate genetic predisposition to skin tumors. Cancer research, 63(8), 1871-1875.