SARS-CoV-2 PCR and antibody positivity in asymptomatic health care workers with a known SARS-CoV-2 exposure: December, 2020 to December, 2021

Rachel Yoken; Caroline A. O'Neil; Kate Peacock; Candice Cass; Meghan A. Wallace; Kelly Alvarado; Mostafa Amor; Emily Struttmann; Daniel Park; David McDonald; Karl Hock; Hilary Babcock; Carey Ann D. Burnham; Christopher W. Farnsworth; Jennie H. Kwon

doi:10.1016/j.ajic.2025.07.005

SARS-CoV-2 PCR and antibody positivity in asymptomatic health care workers with a known SARS-CoV-2 exposure: December, 2020 to December, 2021

Rachel Yoken
, Caroline A. O'Neil
, Kate Peacock
, Candice Cass
, Meghan A. Wallace
, Kelly Alvarado
, Mostafa Amor
, Emily Struttmann
, Daniel Park
, David McDonald
, Karl Hock
, Hilary Babcock
, Carey Ann D. Burnham
, Christopher W. Farnsworth
, Jennie H. Kwon

Research output: Contribution to journal › Article › peer-review

Abstract

In this prospective cohort study, 30 health care personnel with a known SARS-CoV-2 exposure provided oropharyngeal swabs for polymerase chain reaction (PCR) testing and blood specimens for serologic testing at 2 time points postexposure. At a median 7 days postexposure (range, 1-13 days), none had a positive PCR and 1 (3%) had a reactive antibody test. No additional participants were PCR or antibody-positive at a median 25 days postexposure (range, 14-36 days).

Original language	English
Pages (from-to)	1124-1126
Number of pages	3
Journal	American Journal of Infection Control
Volume	53
Issue number	10
DOIs	https://doi.org/10.1016/j.ajic.2025.07.005
State	Published - Oct 2025

Keywords

Health care personnel
Vaccination

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10.1016/j.ajic.2025.07.005

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Yoken, R., O'Neil, C. A., Peacock, K., Cass, C., Wallace, M. A., Alvarado, K., Amor, M., Struttmann, E., Park, D., McDonald, D., Hock, K., Babcock, H., Burnham, C. A. D., Farnsworth, C. W., & Kwon, J. H. (2025). SARS-CoV-2 PCR and antibody positivity in asymptomatic health care workers with a known SARS-CoV-2 exposure: December, 2020 to December, 2021. American Journal of Infection Control, 53(10), 1124-1126. https://doi.org/10.1016/j.ajic.2025.07.005

@article{2e3c1d919e3c478190fa125b35d6292c,

title = "SARS-CoV-2 PCR and antibody positivity in asymptomatic health care workers with a known SARS-CoV-2 exposure: December, 2020 to December, 2021",

abstract = "In this prospective cohort study, 30 health care personnel with a known SARS-CoV-2 exposure provided oropharyngeal swabs for polymerase chain reaction (PCR) testing and blood specimens for serologic testing at 2 time points postexposure. At a median 7 days postexposure (range, 1-13 days), none had a positive PCR and 1 (3\%) had a reactive antibody test. No additional participants were PCR or antibody-positive at a median 25 days postexposure (range, 14-36 days).",

keywords = "Health care personnel, Vaccination",

author = "Rachel Yoken and O'Neil, \{Caroline A.\} and Kate Peacock and Candice Cass and Wallace, \{Meghan A.\} and Kelly Alvarado and Mostafa Amor and Emily Struttmann and Daniel Park and David McDonald and Karl Hock and Hilary Babcock and Burnham, \{Carey Ann D.\} and Farnsworth, \{Christopher W.\} and Kwon, \{Jennie H.\}",

note = "Publisher Copyright: {\textcopyright} 2025 The Authors",

year = "2025",

month = oct,

doi = "10.1016/j.ajic.2025.07.005",

language = "English",

volume = "53",

pages = "1124--1126",

journal = "American Journal of Infection Control",

issn = "0196-6553",

number = "10",

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Yoken, R, O'Neil, CA, Peacock, K, Cass, C, Wallace, MA, Alvarado, K, Amor, M, Struttmann, E, Park, D, McDonald, D, Hock, K, Babcock, H , Burnham, CAD , Farnsworth, CW & Kwon, JH 2025, 'SARS-CoV-2 PCR and antibody positivity in asymptomatic health care workers with a known SARS-CoV-2 exposure: December, 2020 to December, 2021', American Journal of Infection Control, vol. 53, no. 10, pp. 1124-1126. https://doi.org/10.1016/j.ajic.2025.07.005

TY - JOUR

T1 - SARS-CoV-2 PCR and antibody positivity in asymptomatic health care workers with a known SARS-CoV-2 exposure

T2 - December, 2020 to December, 2021

AU - Yoken, Rachel

AU - O'Neil, Caroline A.

AU - Peacock, Kate

AU - Cass, Candice

AU - Wallace, Meghan A.

AU - Alvarado, Kelly

AU - Amor, Mostafa

AU - Struttmann, Emily

AU - Park, Daniel

AU - McDonald, David

AU - Hock, Karl

AU - Babcock, Hilary

AU - Burnham, Carey Ann D.

AU - Farnsworth, Christopher W.

AU - Kwon, Jennie H.

PY - 2025/10

Y1 - 2025/10

N2 - In this prospective cohort study, 30 health care personnel with a known SARS-CoV-2 exposure provided oropharyngeal swabs for polymerase chain reaction (PCR) testing and blood specimens for serologic testing at 2 time points postexposure. At a median 7 days postexposure (range, 1-13 days), none had a positive PCR and 1 (3%) had a reactive antibody test. No additional participants were PCR or antibody-positive at a median 25 days postexposure (range, 14-36 days).

AB - In this prospective cohort study, 30 health care personnel with a known SARS-CoV-2 exposure provided oropharyngeal swabs for polymerase chain reaction (PCR) testing and blood specimens for serologic testing at 2 time points postexposure. At a median 7 days postexposure (range, 1-13 days), none had a positive PCR and 1 (3%) had a reactive antibody test. No additional participants were PCR or antibody-positive at a median 25 days postexposure (range, 14-36 days).

KW - Health care personnel

KW - Vaccination

UR - https://www.scopus.com/pages/publications/105012764585

U2 - 10.1016/j.ajic.2025.07.005

DO - 10.1016/j.ajic.2025.07.005

M3 - Article

C2 - 40683530

AN - SCOPUS:105012764585

SN - 0196-6553

VL - 53

SP - 1124

EP - 1126

JO - American Journal of Infection Control

JF - American Journal of Infection Control

IS - 10

ER -

SARS-CoV-2 PCR and antibody positivity in asymptomatic health care workers with a known SARS-CoV-2 exposure: December, 2020 to December, 2021

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Keywords

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