TY - JOUR
T1 - SARS-CoV-2 active infection prevalence and seroprevalence in the adult population of St. Louis County
AU - Goss, Charles W.
AU - Maricque, Brett B.
AU - Anwuri, Victoria V.
AU - Cohen, Rachel E.
AU - Donaldson, Kate
AU - Johnson, Kimberly J.
AU - Powderly, William G.
AU - Schechtman, Kenneth B.
AU - Schmidt, Spring
AU - Thompson, Jeannette Jackson
AU - Trolard, Anne M.
AU - Wang, Jinli
AU - Geng, Elvin H.
N1 - Funding Information:
This work was supported by the St. Louis County Department of Public Health through the 2020 Coronavirus Aid, Relief, and Economic Security (CARES) Act.
Publisher Copyright:
© 2022 Elsevier Ltd
PY - 2022/7
Y1 - 2022/7
N2 - Background: The true prevalence of COVID-19 is difficult to estimate due to the absence of random population-based testing. To estimate current and past COVID-19 infection prevalence in a large urban area, we conducted a population-based survey in St. Louis County, Missouri. Methods: The population-based survey of active infection (PCR) and seroprevalence (IgG antibodies) of adults (≥18 years) was conducted through random-digit dialing and targeted sampling of St. Louis County residents with oversampling of Black residents. Infection prevalence of residents was estimated using design-based and raking weighting. Results: Between August 17 and October 24, 2020, 1245 residents completed a survey and underwent PCR testing; 1073 residents completed a survey and underwent PCR and IgG testing or self-reported results. Weighted prevalence estimates of residents with active infection were 1.9% (95% CI, 0.4%–3.3%) and 5.6% were ever infected (95% CI, 3.3%–8.0%). Overall infection hospitalization and fatality ratios were 4.9% and 1.4%, respectively. Conclusions: Through October 2020, the percentage of residents that had ever been infected was relatively low. A markedly higher percentage of Black and other minorities compared to White residents were infected with COVID-19. The St. Louis region remained highly vulnerable to widespread infection in late 2020.
AB - Background: The true prevalence of COVID-19 is difficult to estimate due to the absence of random population-based testing. To estimate current and past COVID-19 infection prevalence in a large urban area, we conducted a population-based survey in St. Louis County, Missouri. Methods: The population-based survey of active infection (PCR) and seroprevalence (IgG antibodies) of adults (≥18 years) was conducted through random-digit dialing and targeted sampling of St. Louis County residents with oversampling of Black residents. Infection prevalence of residents was estimated using design-based and raking weighting. Results: Between August 17 and October 24, 2020, 1245 residents completed a survey and underwent PCR testing; 1073 residents completed a survey and underwent PCR and IgG testing or self-reported results. Weighted prevalence estimates of residents with active infection were 1.9% (95% CI, 0.4%–3.3%) and 5.6% were ever infected (95% CI, 3.3%–8.0%). Overall infection hospitalization and fatality ratios were 4.9% and 1.4%, respectively. Conclusions: Through October 2020, the percentage of residents that had ever been infected was relatively low. A markedly higher percentage of Black and other minorities compared to White residents were infected with COVID-19. The St. Louis region remained highly vulnerable to widespread infection in late 2020.
KW - Covid-19
KW - Probability survey
KW - Seroprevalence
UR - http://www.scopus.com/inward/record.url?scp=85129539355&partnerID=8YFLogxK
U2 - 10.1016/j.annepidem.2022.03.002
DO - 10.1016/j.annepidem.2022.03.002
M3 - Article
C2 - 35276338
AN - SCOPUS:85129539355
SN - 1047-2797
VL - 71
SP - 31
EP - 37
JO - Annals of Epidemiology
JF - Annals of Epidemiology
ER -