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SARM1 is a metabolic sensor activated by an increased NMN/NAD
+
ratio to trigger axon degeneration
Matthew D. Figley
, Weixi Gu
, Jeffrey D. Nanson
, Yun Shi
,
Yo Sasaki
, Katie Cunnea
, Alpeshkumar K. Malde
, Xinying Jia
, Zhenyao Luo
, Forhad K. Saikot
, Tamim Mosaiab
, Veronika Masic
, Stephanie Holt
, Lauren Hartley-Tassell
, Helen Y. McGuinness
, Mohammad K. Manik
, Todd Bosanac
, Michael J. Landsberg
, Philip S. Kerry
, Mehdi Mobli
Robert O. Hughes,
Jeffrey Milbrandt
, Bostjan Kobe,
Aaron DiAntonio
, Thomas Ve
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Department of Genetics
Institute of Clinical and Translational Sciences (ICTS)
Center of Regenerative Medicine
Roy and Diana Vagelos Division of Biology & Biomedical Sciences (DBBS)
McDonnell Genome Institute (MGI)
Siteman Cancer Center
COVID-19 Researchers
Department of Developmental Biology
Bursky Center for Human Immunology & Immunotherapy Programs (CHiiPs)
DBBS - Molecular Cell Biology
DBBS - Developmental, Regenerative and Stem Cell Biology
DBBS - Molecular Genetics and Genomics
DBBS - Neurosciences
Hope Center for Neurological Disorders
Brain Tumor Center
Intellectual and Developmental Disabilities Research Center (IDDRC)
Research output
:
Contribution to journal
›
Article
›
peer-review
223
Scopus citations
Overview
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+
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Keyphrases
Axonal Degeneration
100%
Nicotinamide Adenine Dinucleotide (NAD+)
100%
Interleukin-1 Receptor
100%
Metabolic Sensor
100%
Axon
15%
Armadillo Domain
15%
Pathological Features
7%
Neurodegenerative Diseases
7%
Mutagenesis
7%
Biochemical Assay
7%
Metabolic
7%
Nicotinamide Mononucleotide Adenylyltransferase (NMNAT)
7%
Cellular Assay
7%
Biosynthetic Enzymes
7%
Biophysical Assays
7%
Catastrophe
7%
Reporting Structure
7%
Structural Assay
7%
Biochemistry, Genetics and Molecular Biology
Nerve Fiber Degeneration
100%
Interleukin-1 Receptor
100%
Nicotinamide Adenine Dinucleotide
100%
Nicotinamide
100%
Enzyme
20%
Axon
20%
Armadillo Repeat
20%
Metabolite
10%
N-Terminus
10%
Mutagenesis
10%