Sarcoplasmic reticulum ATPase catalyzes hydrolysis of adenyl-5'-yl imidodiphosphate.

Research output: Contribution to journalArticlepeer-review

21 Scopus citations


Sarcoplasmic reticulum ATPase has been found to cleave the ATP analog adenyl-5'-yl imidodiphosphate in a calcium-dependent reaction. The reaction products were determined by 31P NMR to be inorganic phosphate and adenyl-5'-yl phosphoramidate (AMP-PN). AMP-PNP hydrolysis, like ATP hydrolysis, drives active Ca2+ accumulation by sarcoplasmic reticulum vesicles.

Original languageEnglish
Pages (from-to)9793-9795
Number of pages3
JournalJournal of Biological Chemistry
Issue number19
StatePublished - Oct 10 1981


Dive into the research topics of 'Sarcoplasmic reticulum ATPase catalyzes hydrolysis of adenyl-5'-yl imidodiphosphate.'. Together they form a unique fingerprint.

Cite this