TY - JOUR
T1 - Sarcopenia Definition
T2 - The Position Statements of the Sarcopenia Definition and Outcomes Consortium
AU - Bhasin, Shalender
AU - Travison, Thomas G.
AU - Manini, Todd M.
AU - Patel, Sheena
AU - Pencina, Karol M.
AU - Fielding, Roger A.
AU - Magaziner, Jay M.
AU - Newman, Anne B.
AU - Kiel, Douglas P.
AU - Cooper, Cyrus
AU - Guralnik, Jack M.
AU - Cauley, Jane A.
AU - Arai, Hidenori
AU - Clark, Brian C.
AU - Landi, Francesco
AU - Schaap, Laura A.
AU - Pereira, Suzette L.
AU - Rooks, Daniel
AU - Woo, Jean
AU - Woodhouse, Linda J.
AU - Binder, Ellen
AU - Brown, Todd
AU - Shardell, Michelle
AU - Xue, Quian Li
AU - DʼAgostino, Ralph B.
AU - Orwig, Denise
AU - Gorsicki, Greg
AU - Correa-De-Araujo, Rosaly
AU - Cawthon, Peggy M.
N1 - Funding Information:
Everyone who contributed significantly to the work has been listed in the author list. We have obtained written/e-mail consent from all contributors who are not authors and are named in the Acknowledgments section. We thank Lyndon Joseph of the National Institute on Aging (NIA), the project's program officer, for his guidance and oversight of the project. We thank Kevin Wilson and Tom Kelly of Hologic Corporation for their assistance in harmonizing the dual-energy x-ray absorptiometry data. Rosalie Correa-De-Araujo is an employee of the NIA. Her participation in the conference or in the article should not be interpreted as representing the official viewpoint of the US Department of Health and Human Services, the National Institutes of Health, or the NIA, except where noted. Any opinions, findings, conclusions, or recommendations expressed in this publication are those of the authors and do not necessarily reflect the view of the US Department of Agriculture (USDA).
Publisher Copyright:
© 2020 The American Geriatrics Society
PY - 2020/7/1
Y1 - 2020/7/1
N2 - OBJECTIVES: To develop an evidence-based definition of sarcopenia that can facilitate identification of older adults at risk for clinically relevant outcomes (eg, self-reported mobility limitation, falls, fractures, and mortality), the Sarcopenia Definition and Outcomes Consortium (SDOC) crafted a set of position statements informed by a literature review and SDOC's analyses of eight epidemiologic studies, six randomized clinical trials, four cohort studies of special populations, and two nationally representative population-based studies. METHODS: Thirteen position statements related to the putative components of a sarcopenia definition, informed by the SDOC analyses and literature synthesis, were reviewed by an independent international expert panel (panel) iteratively and voted on by the panel during the Sarcopenia Position Statement Conference. Four position statements related to grip strength, three to lean mass derived from dual-energy x-ray absorptiometry (DXA), and four to gait speed; two were summary statements. RESULTS: The SDOC analyses identified grip strength, either absolute or scaled to measures of body size, as an important discriminator of slowness. Both low grip strength and low usual gait speed independently predicted falls, self-reported mobility limitation, hip fractures, and mortality in community-dwelling older adults. Lean mass measured by DXA was not associated with incident adverse health-related outcomes in community-dwelling older adults with or without adjustment for body size. CONCLUSION: The panel agreed that both weakness defined by low grip strength and slowness defined by low usual gait speed should be included in the definition of sarcopenia. These position statements offer a rational basis for an evidence-based definition of sarcopenia. The analyses that informed these position statements are summarized in this article and discussed in accompanying articles in this issue of the journal. J Am Geriatr Soc 68:1410-1418, 2020.
AB - OBJECTIVES: To develop an evidence-based definition of sarcopenia that can facilitate identification of older adults at risk for clinically relevant outcomes (eg, self-reported mobility limitation, falls, fractures, and mortality), the Sarcopenia Definition and Outcomes Consortium (SDOC) crafted a set of position statements informed by a literature review and SDOC's analyses of eight epidemiologic studies, six randomized clinical trials, four cohort studies of special populations, and two nationally representative population-based studies. METHODS: Thirteen position statements related to the putative components of a sarcopenia definition, informed by the SDOC analyses and literature synthesis, were reviewed by an independent international expert panel (panel) iteratively and voted on by the panel during the Sarcopenia Position Statement Conference. Four position statements related to grip strength, three to lean mass derived from dual-energy x-ray absorptiometry (DXA), and four to gait speed; two were summary statements. RESULTS: The SDOC analyses identified grip strength, either absolute or scaled to measures of body size, as an important discriminator of slowness. Both low grip strength and low usual gait speed independently predicted falls, self-reported mobility limitation, hip fractures, and mortality in community-dwelling older adults. Lean mass measured by DXA was not associated with incident adverse health-related outcomes in community-dwelling older adults with or without adjustment for body size. CONCLUSION: The panel agreed that both weakness defined by low grip strength and slowness defined by low usual gait speed should be included in the definition of sarcopenia. These position statements offer a rational basis for an evidence-based definition of sarcopenia. The analyses that informed these position statements are summarized in this article and discussed in accompanying articles in this issue of the journal. J Am Geriatr Soc 68:1410-1418, 2020.
KW - consensus definition of sarcopenia
KW - grip strength cut points
KW - lean mass cut points
KW - mobility disability
KW - sarcopenia
UR - http://www.scopus.com/inward/record.url?scp=85081223437&partnerID=8YFLogxK
U2 - 10.1111/jgs.16372
DO - 10.1111/jgs.16372
M3 - Article
C2 - 32150289
AN - SCOPUS:85081223437
SN - 0002-8614
VL - 68
SP - 1410
EP - 1418
JO - Journal of the American Geriatrics Society
JF - Journal of the American Geriatrics Society
IS - 7
ER -