TY - JOUR
T1 - Sarcopenia, age, atrophy, and myopathy
T2 - Mitochondrial oxidative enzyme activities
AU - Pestronk, Alan
AU - Keeling, Richard
AU - Choksi, Rati
N1 - Publisher Copyright:
© 2016 Wiley Periodicals, Inc.
PY - 2017/7
Y1 - 2017/7
N2 - Introduction: We studied mitochondrial impairment as a factor in the pathologic equivalent of sarcopenia, muscle fiber atrophy associated with increased age. Methods: Mitochondrial oxidative enzyme activities and coenzyme Q10 levels were measured in frozen human proximal limb muscles with combined age and atrophy, age alone, atrophy alone, denervation, immune myopathies, and mitochondrial disorders with ophthalmoplegia. Results: Sarcopenia (age and atrophy) had reduced mean activities of mitochondrial Complexes I, II, and II+III, with severe reduction of Complex I activity in 54% of patients. Atrophy, and specific denervation atrophy, had similar patterns of changes. Age alone had moderately reduced Complex I activity. Mitochondrial myopathies had mildly lower Complex IV activity. Immune myopathies had unchanged enzyme activities. Conclusions: Mitochondrial oxidative enzyme activities, especially Complex I, but also Complexes II and II+III, are reduced in muscles with the pathologic equivalent of sarcopenia. Individually, atrophy and age have different patterns of oxidative enzyme changes. Muscle Nerve 56: 122–128, 2017.
AB - Introduction: We studied mitochondrial impairment as a factor in the pathologic equivalent of sarcopenia, muscle fiber atrophy associated with increased age. Methods: Mitochondrial oxidative enzyme activities and coenzyme Q10 levels were measured in frozen human proximal limb muscles with combined age and atrophy, age alone, atrophy alone, denervation, immune myopathies, and mitochondrial disorders with ophthalmoplegia. Results: Sarcopenia (age and atrophy) had reduced mean activities of mitochondrial Complexes I, II, and II+III, with severe reduction of Complex I activity in 54% of patients. Atrophy, and specific denervation atrophy, had similar patterns of changes. Age alone had moderately reduced Complex I activity. Mitochondrial myopathies had mildly lower Complex IV activity. Immune myopathies had unchanged enzyme activities. Conclusions: Mitochondrial oxidative enzyme activities, especially Complex I, but also Complexes II and II+III, are reduced in muscles with the pathologic equivalent of sarcopenia. Individually, atrophy and age have different patterns of oxidative enzyme changes. Muscle Nerve 56: 122–128, 2017.
KW - aging
KW - atrophy
KW - mitochondria
KW - muscle
KW - myopathy
KW - sarcopenia
UR - http://www.scopus.com/inward/record.url?scp=85012245116&partnerID=8YFLogxK
U2 - 10.1002/mus.25442
DO - 10.1002/mus.25442
M3 - Article
C2 - 27759889
AN - SCOPUS:85012245116
SN - 0148-639X
VL - 56
SP - 122
EP - 128
JO - Muscle and Nerve
JF - Muscle and Nerve
IS - 1
ER -