Sarcomatoid Morphology in Pediatric Langerhans Cell Neoplasm Does Not Always Predict Aggressive Clinical Course

Sam Sirotnikov, Louis P. Dehner, José E. Velázquez Vega, Jinjun Cheng

Research output: Contribution to journalArticlepeer-review

Abstract

Langerhans cell sarcoma (LCS), a rare malignant neoplasm in the general category of myeloid neoplasms characterized by overtly malignant Langerhans cells (LC) with conspicuous mitotic activity including atypical forms. Although most cases occur in adults, rare examples of LCS have been reported in children with variable clinical outcome. We present 2 childhood cases of Langerhans cell neoplasm with high grade sarcomatous features and OSBPL9::BRAF fusion and BRAF V600E mutation.

Original languageEnglish
JournalPediatric and Developmental Pathology
DOIs
StateAccepted/In press - 2024

Keywords

  • BRAF V600E
  • diagnostic criteria
  • histiocytosis
  • LCH
  • LCS
  • malignancy

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