TY - JOUR
T1 - Sarcolemmal KATP channels
T2 - What do we really know?
AU - Flagg, Thomas P.
AU - Nichols, Colin G.
PY - 2005/7
Y1 - 2005/7
N2 - KATP channels are present at an extremely high density in the heart, and we know from in vitro studies that channel activation causes dramatic action potential shortening and contractile failure. But, if and when this happens in vivo is still a matter of debate. Twenty one years of intense study have led to a well-developed understanding of the molecular basis of K ATP channel activity. Structure-function studies, together with cellular experiments probing regulatory molecules have told us much about the way the KATP channel can activate, and gene-targeting and proteomic tools have further elucidated determinants of in vivo function. However, the true physiological determinants of sarcolemmal KATP activity remain elusive, we still await full illumination of the role of the channel in the intact heart.
AB - KATP channels are present at an extremely high density in the heart, and we know from in vitro studies that channel activation causes dramatic action potential shortening and contractile failure. But, if and when this happens in vivo is still a matter of debate. Twenty one years of intense study have led to a well-developed understanding of the molecular basis of K ATP channel activity. Structure-function studies, together with cellular experiments probing regulatory molecules have told us much about the way the KATP channel can activate, and gene-targeting and proteomic tools have further elucidated determinants of in vivo function. However, the true physiological determinants of sarcolemmal KATP activity remain elusive, we still await full illumination of the role of the channel in the intact heart.
KW - Action potential shortening
KW - Contractile failure
KW - K channel
UR - http://www.scopus.com/inward/record.url?scp=20544461944&partnerID=8YFLogxK
U2 - 10.1016/j.yjmcc.2005.01.005
DO - 10.1016/j.yjmcc.2005.01.005
M3 - Review article
C2 - 15978903
AN - SCOPUS:20544461944
VL - 39
SP - 61
EP - 70
JO - Journal of Molecular and Cellular Cardiology
JF - Journal of Molecular and Cellular Cardiology
SN - 0022-2828
IS - 1
ER -