Sarcolemmal KATP channels in the heart: Molecular mechanisms brought to light, but physiologic consequences still in the dark

Thomas P. Flagg, Colin G. Nichols

Research output: Contribution to journalReview articlepeer-review

12 Scopus citations

Abstract

ATP-sensitive potassium (KATP) channels are inhibited by intracellular ATP and thus couple the metabolic state of the cell to its electrical activity. Tremendous progress has been made in the identification of the molecular basis of KATP channel function and regulation. The answer to one key question, however, has proven elusive: What are the precise conditions for, and functional consequences of, sarcolemmal KATP activation in physiologic and pathophysiologic states? Here we consider recent studies of the molecular basis of cardiac KATP channel activity and the role of these channels in cardiac function during ischemia.

Original languageEnglish
Pages (from-to)1195-1198
Number of pages4
JournalJournal of cardiovascular electrophysiology
Volume12
Issue number10
DOIs
StatePublished - Jan 1 2001

Keywords

  • ATP
  • Ischemia
  • Kir6.2 subunit
  • Potassium channel
  • Preconditioning
  • SUR2A subunit

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