Sarcoidosis, granulomas and myopathy syndromes: A clinical-pathology review

Mark Garret, Alan Pestronk

Research output: Contribution to journalArticlepeer-review

2 Scopus citations


Muscle involvement in sarcoidosis is common by pathologic analysis, but symptomatic disorders are less frequent. Sarcoidosis-related muscle pathology includes non-caseating granulomas, muscle fiber changes that are diffuse or anatomically related to granulomas, and perimysial connective tissue with histiocyte-associated damage. The mechanisms by which granulomas form, enlarge and damage muscle tissues are incompletely understood. Sarcoidosis-related clinical syndromes with muscle involvement include: chronic myopathies with proximal weakness; nodular disorders; subacute onset disorders involving proximal or eye muscles; myalgia or fatigue syndromes; and, possibly, inclusion body myositis-like disorders. Corticosteroid treatment may benefit some syndromes, but clinical trials are necessary.

Original languageEnglish
Article number577975
JournalJournal of Neuroimmunology
StatePublished - Dec 15 2022


  • Granuloma
  • Myopathy
  • Myositis
  • Sarcoidosis


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