TY - JOUR
T1 - Sarcoidosis, granulomas and myopathy syndromes
T2 - A clinical-pathology review
AU - Garret, Mark
AU - Pestronk, Alan
N1 - Publisher Copyright:
© 2022 Elsevier B.V.
PY - 2022/12/15
Y1 - 2022/12/15
N2 - Muscle involvement in sarcoidosis is common by pathologic analysis, but symptomatic disorders are less frequent. Sarcoidosis-related muscle pathology includes non-caseating granulomas, muscle fiber changes that are diffuse or anatomically related to granulomas, and perimysial connective tissue with histiocyte-associated damage. The mechanisms by which granulomas form, enlarge and damage muscle tissues are incompletely understood. Sarcoidosis-related clinical syndromes with muscle involvement include: chronic myopathies with proximal weakness; nodular disorders; subacute onset disorders involving proximal or eye muscles; myalgia or fatigue syndromes; and, possibly, inclusion body myositis-like disorders. Corticosteroid treatment may benefit some syndromes, but clinical trials are necessary.
AB - Muscle involvement in sarcoidosis is common by pathologic analysis, but symptomatic disorders are less frequent. Sarcoidosis-related muscle pathology includes non-caseating granulomas, muscle fiber changes that are diffuse or anatomically related to granulomas, and perimysial connective tissue with histiocyte-associated damage. The mechanisms by which granulomas form, enlarge and damage muscle tissues are incompletely understood. Sarcoidosis-related clinical syndromes with muscle involvement include: chronic myopathies with proximal weakness; nodular disorders; subacute onset disorders involving proximal or eye muscles; myalgia or fatigue syndromes; and, possibly, inclusion body myositis-like disorders. Corticosteroid treatment may benefit some syndromes, but clinical trials are necessary.
KW - Granuloma
KW - Myopathy
KW - Myositis
KW - Sarcoidosis
UR - http://www.scopus.com/inward/record.url?scp=85139723628&partnerID=8YFLogxK
U2 - 10.1016/j.jneuroim.2022.577975
DO - 10.1016/j.jneuroim.2022.577975
M3 - Article
C2 - 36228383
AN - SCOPUS:85139723628
SN - 0165-5728
VL - 373
JO - Journal of Neuroimmunology
JF - Journal of Neuroimmunology
M1 - 577975
ER -