Sanpodo: A context-dependent activator and inhibitor of Notch signaling during asymmetric divisions

A. Burcu Babaoglan, Kate M. O'Connor-Giles, Hemlata Mistry, Adam Schickedanz, Beth A. Wilson, James B. Skeath

Research output: Contribution to journalArticle

28 Scopus citations

Abstract

Asymmetric cell divisions generate sibling cells of distinct fates ('A', 'B') and constitute a fundamental mechanism that creates cell-type diversity in multicellular organisms. Antagonistic interactions between the Notch pathway and the intrinsic cell-fate determinant Numb appear to regulate asymmetric divisions in flies and vertebrates. During these divisions, productive Notch signaling requires sanpodo, which encodes a novel transmembrane protein. Here, we demonstrate that Drosophila sanpodo plays dual role to regulate Notch signaling during asymmetric divisions - amplifying Notch signaling in the absence of Numb in the 'A' daughter cell and inhibiting Notch signaling in the presence of Numb in the 'B' daughter cell. In so doing, sanpodo ensures the asymmetry in Notch signaling levels necessary for the acquisition of distinct fates by the two daughter cells. These findings answer long-standing questions about the restricted ability of Numb and Sanpodo to inhibit and to promote, respectively, Notch signaling during asymmetric divisions.

Original languageEnglish
Pages (from-to)4089-4098
Number of pages10
JournalDevelopment
Volume136
Issue number24
DOIs
StatePublished - Dec 11 2009

Keywords

  • Asymmetric divisions
  • Drosophila
  • Notch
  • Numb
  • Sanpodo

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    Babaoglan, A. B., O'Connor-Giles, K. M., Mistry, H., Schickedanz, A., Wilson, B. A., & Skeath, J. B. (2009). Sanpodo: A context-dependent activator and inhibitor of Notch signaling during asymmetric divisions. Development, 136(24), 4089-4098. https://doi.org/10.1242/dev.040386