TY - JOUR
T1 - Sampling and signaling in plasmacytoid dendritic cells
T2 - the potential roles of Siglec-H
AU - Blasius, Amanda L.
AU - Colonna, Marco
N1 - Funding Information:
We thank Julia Klesney-Tait, Isaiah Turnbull, Winifried Barchet, Daved Fremont and the referee for helpful suggestions and critiques. M.C. is supported by NIH grant R01CA109 673-01A1 and A.L.B. by Infectious Diseases Training grant 2T32A10717226.
PY - 2006/6
Y1 - 2006/6
N2 - Plasmacytoid dendritic cells (pDCs) detect viruses through toll-like receptor (TLR)7 and TLR9 and respond by secreting type I interferons (IFNs). Because TLR7 and TLR9 are present in endosomes, a mechanism is required to capture and deliver viruses to TLRs. A member of the sialic acid binding Ig-like lectin (Siglec) family, Siglec-H, has recently been identified as a specific surface marker for pDCs in mice. Siglec-H is endocytosed and can mediate the uptake of antigens for processing and presentation. Thus, Siglec-H might have a role in the capture of viruses or other pathogens for their delivery to intracellular TLRs. Paradoxically, Siglec-H also transmits intracellular signals through the associated adaptor DAP12, which reduces pDC responses to TLR ligands. In this review, we discuss models to explain the potential outcomes of Siglec-H engagement in the pDC secretion of type I IFN.
AB - Plasmacytoid dendritic cells (pDCs) detect viruses through toll-like receptor (TLR)7 and TLR9 and respond by secreting type I interferons (IFNs). Because TLR7 and TLR9 are present in endosomes, a mechanism is required to capture and deliver viruses to TLRs. A member of the sialic acid binding Ig-like lectin (Siglec) family, Siglec-H, has recently been identified as a specific surface marker for pDCs in mice. Siglec-H is endocytosed and can mediate the uptake of antigens for processing and presentation. Thus, Siglec-H might have a role in the capture of viruses or other pathogens for their delivery to intracellular TLRs. Paradoxically, Siglec-H also transmits intracellular signals through the associated adaptor DAP12, which reduces pDC responses to TLR ligands. In this review, we discuss models to explain the potential outcomes of Siglec-H engagement in the pDC secretion of type I IFN.
UR - http://www.scopus.com/inward/record.url?scp=33744909412&partnerID=8YFLogxK
U2 - 10.1016/j.it.2006.04.005
DO - 10.1016/j.it.2006.04.005
M3 - Article
C2 - 16679063
AN - SCOPUS:33744909412
SN - 1471-4906
VL - 27
SP - 255
EP - 260
JO - Trends in Immunology
JF - Trends in Immunology
IS - 6
ER -