TY - JOUR
T1 - Salivary gland transfer to prevent radiation-induced xerostomia
T2 - A systematic review and meta-analysis
AU - Sood, Amit J.
AU - Fox, Nyssa F.
AU - O'Connell, Brendan P.
AU - Lovelace, Tiffany L.
AU - Nguyen, Shaun A.
AU - Sharma, Anand K.
AU - Hornig, Joshua D.
AU - Day, Terry A.
PY - 2014/2
Y1 - 2014/2
N2 - Salivary gland transfer (SGT) has the potential to prevent radiation-induced xerostomia. We attempt to analyze the efficacy of SGT in prevention of xerostomia and maintenance of salivary flow rates after radiation treatment (XRT). Systematic review and meta-analysis. Primary endpoint was efficacy of SGT in prevention of radiation-induced xerostomia. Secondary endpoint was change from baseline of unstimulated and stimulated salivary flow rates after XRT. Seven articles, accruing data from 12 institutions, met inclusion criteria. In a total of 177 patients at mean follow-up of 22.7 months, SGT prevented radiation-induced xerostomia in 82.7% (95% CI, 76.6-87.7%) of patients. Twelve months after XRT, unstimulated and stimulated salivary flow rates rose to 88% and 76% of baseline values, respectively. In comparison to control subjects twelve months after XRT, SGT subjects' unstimulated (75% vs. 11%) and stimulated (86% vs. 8%) salivary flow rates were drastically higher in SGT patients. Salivary gland transfer appears to be highly effective in preventing the incidence of xerostomia in patients receiving definitive head and neck radiation therapy.
AB - Salivary gland transfer (SGT) has the potential to prevent radiation-induced xerostomia. We attempt to analyze the efficacy of SGT in prevention of xerostomia and maintenance of salivary flow rates after radiation treatment (XRT). Systematic review and meta-analysis. Primary endpoint was efficacy of SGT in prevention of radiation-induced xerostomia. Secondary endpoint was change from baseline of unstimulated and stimulated salivary flow rates after XRT. Seven articles, accruing data from 12 institutions, met inclusion criteria. In a total of 177 patients at mean follow-up of 22.7 months, SGT prevented radiation-induced xerostomia in 82.7% (95% CI, 76.6-87.7%) of patients. Twelve months after XRT, unstimulated and stimulated salivary flow rates rose to 88% and 76% of baseline values, respectively. In comparison to control subjects twelve months after XRT, SGT subjects' unstimulated (75% vs. 11%) and stimulated (86% vs. 8%) salivary flow rates were drastically higher in SGT patients. Salivary gland transfer appears to be highly effective in preventing the incidence of xerostomia in patients receiving definitive head and neck radiation therapy.
KW - Head and neck cancer
KW - Radiation-induced xerostomia
KW - Radiotherapy
KW - Salivary gland transfer
KW - Xerostomia
UR - http://www.scopus.com/inward/record.url?scp=84891826247&partnerID=8YFLogxK
U2 - 10.1016/j.oraloncology.2013.10.010
DO - 10.1016/j.oraloncology.2013.10.010
M3 - Review article
C2 - 24189058
AN - SCOPUS:84891826247
SN - 1368-8375
VL - 50
SP - 77
EP - 83
JO - Oral Oncology
JF - Oral Oncology
IS - 2
ER -