Safety of aspirin desensitization in patients with reported aspirin allergy and cardiovascular disease

Kathryn L. McMullan, H. James Wedner

Research output: Contribution to journalArticlepeer-review

31 Scopus citations

Abstract

Background: Aspirin (ASA) is the drug of choice in patients with coronary artery disease for primary and secondary prevention. This poses a problem for those patients reporting hypersensitivity to this drug or class of drugs. Hypothesis: Desensitization to ASA may be carried out safely and effectively in patients with reported ASA or nonsteroidal anti-inflammatory drug (NSAID) hypersensitivity needing ASA for cardiac indications. Our 7-step protocol is one choice for a rapid desensitization protocol. Methods: A retrospective chart review was conducted evaluating ASA desensitization in patients with reported ASA or NSAID hypersensitivity and a cardiac indication for ASA. Results: In 160 evaluations over 15 years, 89 desensitizations were performed in both the inpatient and outpatient setting with only 16 reactions (18%). Eleven of these 16 patients (68.7%) were able to take daily ASA. Twenty-six desensitization procedures were performed with our 7-step rapid desensitization protocol in 10 inpatients and 16 outpatients with 3 reactions (18.75% of reactions). Initial reaction to ASA involving angioedema and reacting to ASA within the past year increased the risk of having a reaction to desensitization. Conclusions: Desensitization may be safely performed in patients with reported ASA or NSAID hypersensitivity and a cardiac indication for ASA. Our 7-step rapid protocol may be used in both the inpatient and outpatient setting to desensitize these patients. Patients who had angioedema with ASA ingestion or a reaction to ASA within the past year are at higher risk for reaction during the desensitization protocol. The authors have no funding, financial relationships, or conflicts of interest to disclose.

Original languageEnglish
Pages (from-to)25-30
Number of pages6
JournalClinical Cardiology
Volume36
Issue number1
DOIs
StatePublished - Jan 2013

Fingerprint

Dive into the research topics of 'Safety of aspirin desensitization in patients with reported aspirin allergy and cardiovascular disease'. Together they form a unique fingerprint.

Cite this