Safety and Short-Term Outcomes for Infants < 2.5 kg Undergoing PDA Device Closure: A C3PO Registry Study

Oliver M. Barry, Todd M. Gudausky, David T. Balzer, Martin L. Bocks, Brian A. Boe, Ryan Callahan, Howaida El-Said, Michael J. Farias, Susan Foerster, Bryan H. Goldstein, Ralf J. Holzer, Dana Janssen, Philip Levy, Michael L. O’Byrne, Grace Rahman, Shyam Sathanandam, Shabana Shahanavaz, Wendy Whiteside, Mariel E. Turner

Research output: Contribution to journalArticlepeer-review

4 Scopus citations

Abstract

To evaluate short-term procedural outcomes and safety for infants < 2.5 kg who underwent catheterization with intended patent ductus arteriosus (PDA) device closure in a multi-center registry, as performance of this procedure becomes widespread. A multi-center retrospective review was performed using data from the Congenital Cardiac Catheterization Project on Outcomes (C3PO) registry. Data were collected for all intended cases of PDA closure in infants < 2.5 kg from April 2019 to December 2020 at 13 participating sites. Successful device closure was defined as device placement at the conclusion of the catheterization. Procedural outcomes and adverse events (AE) were described, and associations between patient characteristics, procedural outcomes and AEs were analyzed. During the study period, 300 cases were performed with a median weight of 1.0 kg (range 0.7–2.4). Successful device closure was achieved in 98.7% of cases with a 1.7% incidence of level 4/5 AEs, including one periprocedural mortality. Neither failed device placement nor adverse events were significantly associated with patient age, weight or institutional volume. Higher incidence of adverse events associated with patients who had non-cardiac problems (p = 0.017) and cases with multiple devices attempted (p = 0.064). Transcatheter PDA closure in small infants can be performed with excellent short-term outcomes and safety across institutions with variable case volume.

Original languageEnglish
Pages (from-to)1406-1413
Number of pages8
JournalPediatric Cardiology
Volume44
Issue number6
DOIs
StatePublished - Aug 2023

Keywords

  • Cardiac catheterization
  • Cardiovascular interventions
  • Device occlusion
  • Patent ductus arteriosus

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