Safety and efficacy of subthalamic nucleus deep brain stimulation performed with limited intraoperative mapping for treatment of Parkinson's disease

Samer D. Tabbal, Fredy J. Revilla, Jonathan W. Mink, Patricia Schneider-Gibson, Angela R. Wernle, Gabriel A. De Erausquin, Joel S. Perlmutter, Keith M. Rich, Joshua L. Dowling

Research output: Contribution to journalArticle

32 Scopus citations

Abstract

OBJECTIVE: The aim of this study is to establish the safety and efficacy of bilateral subthalamic nucleus (STN) deep brain stimulation (DBS) in Parkinson's disease (PD) patients with disabling motor fluctuations performed with an expedient procedure with limited intraoperative mapping. METHODS: Bilateral STN DBS systems were implanted in 110 PD patients. Targeting of STN was achieved with T2-weighted magnetic resonance imaging guidance and a stereotactic navigation system confirmed by limited electrophysiological mapping. The safety of the procedure was analyzed in all 110 patients. The efficacy of the procedure was assessed in the practically-defined off medication state in the 72 patients who underwent evaluations 3 to 12 months after electrode implantation. RESULTS: Adverse effects were infrequent and transient with no incidence of death, hemiparesis, or seizure. In the 72 patients, STN DBS reduced total Unified Parkinson's Disease Rating Scale motor scores at the time of the follow-up evaluation by 47% from 43.4 ± 16.1 with stimulators off to 22.8 ± 11.6 with stimulators on (P < 0.001). The changes in Unified Parkinson's Disease Rating Scale motor subscores improved as follows: rest tremor, 74% (P < 0.001); rigidity, 58% (P < 0.001); bradykinesia, 37% (P < 0.001); pull test, 35% (P < 0.001); gait, 44% (P < 0.001); axial signs, 42% (P < 0.001); and speech, 13% (P = 0.002). The prescribed total daily levodopa-equivalent dose decreased 45 ± 32%. We averaged 1.3 ± 0.9 electrodes passes per lead implantation. The mean operating time from the mounting of the stereotactic frame to its removal was 5 hours 42 minutes (median, 5 h 25 min; standard deviation, 1 h 12 min). CONCLUSION: This STN DBS surgical technique for PD is expedient with effective outcomes and low complication rates.

Original languageEnglish
Pages (from-to)ONS-119-ONS-127
JournalNeurosurgery
Volume61
Issue number3 SUPPL.
DOIs
StatePublished - Sep 1 2007

Keywords

  • Deep brain stimulation
  • Magnetic resonance imaging
  • Microelectrode recording
  • Movement disorder
  • Parkinson's disease
  • Subthalamic nucleus
  • Surgical approach

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