TY - JOUR
T1 - S-nitrosothiol signaling in respiratory biology
AU - Gaston, Benjamin
AU - Singel, David
AU - Doctor, Allan
AU - Stamler, Jonathan S.
PY - 2006/6/1
Y1 - 2006/6/1
N2 - Genetic and biochemical data demonstrate a pivotal role for S-nitrosothiols (SNOs) in mediating the actions of nitric oxide synthases (NOSs). SNOs serve to convey NO bioactivity and to regulate protein function. This understanding is of immediate interest to the pulmonary clinical and research communities. This article reviews the following: (1) biochemical and cellular evidence that SNOs in amino acids, peptides, and proteins elicit NOS-dependent signaling in the respiratory system and (2) studies that link SNO signaling to pulmonary medicine. SNO-mediated signaling is involved in the regulation of minute ventilation, ventilation-perfusion matching, pulmonary arterial pressure, basal airway tone, and respiratory and peripheral muscle function. Derangements in SNO signaling are implicated in many disorders relevant to pulmonary and critical care medicine, including apnea, hypoxemia, pulmonary hypertension, asthma, cystic fibrosis, pneumonia, and septic shock.
AB - Genetic and biochemical data demonstrate a pivotal role for S-nitrosothiols (SNOs) in mediating the actions of nitric oxide synthases (NOSs). SNOs serve to convey NO bioactivity and to regulate protein function. This understanding is of immediate interest to the pulmonary clinical and research communities. This article reviews the following: (1) biochemical and cellular evidence that SNOs in amino acids, peptides, and proteins elicit NOS-dependent signaling in the respiratory system and (2) studies that link SNO signaling to pulmonary medicine. SNO-mediated signaling is involved in the regulation of minute ventilation, ventilation-perfusion matching, pulmonary arterial pressure, basal airway tone, and respiratory and peripheral muscle function. Derangements in SNO signaling are implicated in many disorders relevant to pulmonary and critical care medicine, including apnea, hypoxemia, pulmonary hypertension, asthma, cystic fibrosis, pneumonia, and septic shock.
KW - Asthma
KW - Cystic fibrosis
KW - Pulmonary hypertension
KW - S-nitrosoglutathione
KW - S-nitrosohemoglobin
KW - S-nitrosylation
UR - http://www.scopus.com/inward/record.url?scp=33744908081&partnerID=8YFLogxK
U2 - 10.1164/rccm.200510-1584PP
DO - 10.1164/rccm.200510-1584PP
M3 - Review article
C2 - 16528016
AN - SCOPUS:33744908081
SN - 1073-449X
VL - 173
SP - 1186
EP - 1193
JO - American journal of respiratory and critical care medicine
JF - American journal of respiratory and critical care medicine
IS - 11
ER -