Runx2 inhibits chondrocyte proliferation and hypertrophy through its expression in the perichondrium

Eiichi Hinoi, Peter Bialek, You Tzung Chen, Marie Therese Rached, Yoram Groner, Richard R. Behringer, David M. Ornitz, Gerard Karsenty

Research output: Contribution to journalArticle

112 Scopus citations

Abstract

The perichondrium, a structure made of undifferentiated mesenchymal cells surrounding growth plate cartilage, regulates chondrocyte maturation through poorly understood mechanisms. Analyses of loss- and gain-of-function models show that Twist-1, whose expression in cartilage is restricted to perichondrium, favors chondrocyte maturation in a Runx2-dependent manner. Runx2, in turn, enhances perichondrial expression of Fgf18, a regulator of chondrocyte maturation. Accordingly, compound heterozygous embryos for Runx2 and Fgf18 deletion display the same chondrocyte maturation phenotype as Fgf18-null embryos. This study identifies a transcriptional basis for the inhibition of chondrocyte maturation by perichondrium and reveals that Runx2 fulfills antagonistic functions during chondrogenesis.

Original languageEnglish
Pages (from-to)2937-2942
Number of pages6
JournalGenes and Development
Volume20
Issue number21
DOIs
StatePublished - Nov 1 2006

Keywords

  • Chondrocyte maturation
  • FGF18
  • Perichondrium
  • Runx2
  • Twist-1

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    Hinoi, E., Bialek, P., Chen, Y. T., Rached, M. T., Groner, Y., Behringer, R. R., Ornitz, D. M., & Karsenty, G. (2006). Runx2 inhibits chondrocyte proliferation and hypertrophy through its expression in the perichondrium. Genes and Development, 20(21), 2937-2942. https://doi.org/10.1101/gad.1482906