Running to stand still: BCR-like signaling suppresses type I IFN responses in pDC

Melissa K. Swiecki, Marco Colonna

Research output: Contribution to journalComment/debate

5 Scopus citations

Abstract

Plasmacytoid dendritic cells (pDC) specialize in the secretion of type I interferon (IFN). Although multiple pathways that modulate type I IFN responses have been described they are inadequately defined. In this issue of the European Journal of Immunology, evidence for a B cell receptor (BCR)-like signaling cascade in pDC that suppresses type I IFN production is provided.

Original languageEnglish
Pages (from-to)3327-3329
Number of pages3
JournalEuropean Journal of Immunology
Volume37
Issue number12
DOIs
StatePublished - Dec 2007

Keywords

  • Signaling
  • Signalosome
  • Type 1 IFN
  • pDC

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