Running to stand still: BCR-like signaling suppresses type I IFN responses in pDC

Melissa K. Swiecki; Marco Colonna

doi:10.1002/eji.200737944

Running to stand still: BCR-like signaling suppresses type I IFN responses in pDC

Melissa K. Swiecki, Marco Colonna

Research output: Contribution to journal › Comment/debate

6 Scopus citations

Abstract

Plasmacytoid dendritic cells (pDC) specialize in the secretion of type I interferon (IFN). Although multiple pathways that modulate type I IFN responses have been described they are inadequately defined. In this issue of the European Journal of Immunology, evidence for a B cell receptor (BCR)-like signaling cascade in pDC that suppresses type I IFN production is provided.

Original language	English
Pages (from-to)	3327-3329
Number of pages	3
Journal	European Journal of Immunology
Volume	37
Issue number	12
DOIs	https://doi.org/10.1002/eji.200737944
State	Published - Dec 2007

Keywords

Signaling
Signalosome
Type 1 IFN
pDC

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10.1002/eji.200737944

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title = "Running to stand still: BCR-like signaling suppresses type I IFN responses in pDC",

abstract = "Plasmacytoid dendritic cells (pDC) specialize in the secretion of type I interferon (IFN). Although multiple pathways that modulate type I IFN responses have been described they are inadequately defined. In this issue of the European Journal of Immunology, evidence for a B cell receptor (BCR)-like signaling cascade in pDC that suppresses type I IFN production is provided.",

keywords = "Signaling, Signalosome, Type 1 IFN, pDC",

author = "Swiecki, {Melissa K.} and Marco Colonna",

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AU - Swiecki, Melissa K.

AU - Colonna, Marco

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N2 - Plasmacytoid dendritic cells (pDC) specialize in the secretion of type I interferon (IFN). Although multiple pathways that modulate type I IFN responses have been described they are inadequately defined. In this issue of the European Journal of Immunology, evidence for a B cell receptor (BCR)-like signaling cascade in pDC that suppresses type I IFN production is provided.

AB - Plasmacytoid dendritic cells (pDC) specialize in the secretion of type I interferon (IFN). Although multiple pathways that modulate type I IFN responses have been described they are inadequately defined. In this issue of the European Journal of Immunology, evidence for a B cell receptor (BCR)-like signaling cascade in pDC that suppresses type I IFN production is provided.

KW - Signaling

KW - Signalosome

KW - Type 1 IFN

KW - pDC

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M3 - Comment/debate

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AN - SCOPUS:37549045597

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EP - 3329

JO - European Journal of Immunology

JF - European Journal of Immunology

IS - 12

ER -

Running to stand still: BCR-like signaling suppresses type I IFN responses in pDC

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Keywords

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