RTOG quality assurance guidelines for clinical trials using hyperthermia for deep-seated malignancy

Michael D. Sapozink, Peter M. Corry, Daniel S. Kapp, Robert J. Myerson, M. W. Dewhirst, B. Emami, T. Herman, S. Prionas, T. Ryan, T. Samulski, S. Sapareto, P. Shrivastava, P. Stauffer, F. Waterman

    Research output: Contribution to journalArticlepeer-review

    35 Scopus citations

    Abstract

    Quality assurance has been vague or lacking in many previous hyperthermia trials. Recent publications by the Hyperthermia Physics Center, the Center for Devices and Regulatory Health, and the Radiation Therapy Oncology Group have described general guidelines for quality assurance in equipment reliability and reproducibility, superficial applications, and microwave techniques. The present report details quality assurance factors that are believed to be important for hyperthermia of deep clinical sites, defined as extending as least 3 cm beyond the skin surface. This document will discuss patient and physician factors, as well as thermometric accuracy, assessment of specific absorption rates (SAR), assurance of adequate coverage of tumors by the energy deposition pattern of the treatment device, and recommended documentation of the location, quantity, and frequency of treatment, specifically oriented to deep hyperthermia. The recommendations are structured to facilitate compliance in multiinstitutional trials.

    Original languageEnglish
    Pages (from-to)1109-1115
    Number of pages7
    JournalInternational journal of radiation oncology, biology, physics
    Volume20
    Issue number5
    DOIs
    StatePublished - May 1 1991

    Keywords

    • Clinical trials
    • Deep hyperthermia
    • Quality assurance

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